文献类型：期刊文献

英文题名：Novel Galactosyl Moiety-Conjugated Furylchalcones Synthesized Facilely Display Significant Regulatory Effect on Plant Growth

作者：Liu, Xuefeng[1];Chen, Yongjun[1];Deng, Yunfei[1];Xiao, Ciying[2];Luan, Shaorong[3];Huang, Qingchun[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Biochem Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2022

卷号：70

期号：6

起止页码：1766

外文期刊名：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

收录：;EI(收录号：20220711627407);WOS:【SCI-EXPANDED(收录号:WOS:000756703000002)】；

基金：This work was supported by the Project of the Innovation Action Plan of the Shanghai Municipal Science and Technology Commission of China (21S11901400, 22N41900100) .

语种：英文

外文关键词：galactosyl furylchalcones; plant growth; herbicidal activity; syntheses; molecular docking

摘要：The expansion of weed infestation has increased the demand on new herbicides. A series of novel galactosyl moietyconjugated furylchalcones was facilely synthesized in which the furyl group (A ring) was combined with the substituted benzene group (B ring), and a galactosyl moiety was introduced. All these galactosyl furylchalcones were predicted to be phloem-mobile. Most of the galactosyl furylchalcones significantly promoted early seedling growth of sorghum and barnyardgrass under dark conditions, but all of them revealed considerable anti-growth ability on illuminated pot plants; especially, 1-(3 '-(4 ''-O-beta-Dgalactopyranosyl)furyl)-3-(4 ''-nitrophenyl)-2-en-1-one (B11) had a better herbicidal activity against rapeseed and Chinese amaranth than haloxyfop-R-methyl. The median efficient concentrations (EC50) of compound B11 against cucumber and wheat were 9.55 and 26.97 mg/L, respectively, also showing a stronger suppressing capacity than 2,4-D. Molecular docking with phosphoenolpyruvate carboxylase protein showed a stable binding conformation in which the galactosyl group interacted with LYS363 and GLU369, the furan ring and carbonyl bound with ARG184, and the crosslink of the nitro group with GLU240 formed a salt bridge. The results demonstrate that galactosyl furylchalcones possess the great potential as new herbicides for weed management, and further evaluations on more weeds are required for practical application.