文献类型：期刊文献

英文题名：Palladium-Catalyzed [4+4] Cycloaddition of Homo-TMM All-Carbon 1,4-Dipole Precursors for Construction of Benzofuro[3,2-b]azocines and Furo[3,2-b]azocines

作者：Chen, Ying[1];Zang, Meng[1];Wang, Weijie[1];Liu, Yang-Zi[2];Luo, Xiaoyan[1];Deng, Wei-Ping[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Sch Pharm, Shanghai 200237, Peoples R China;[2]Zhejiang Normal Univ, Coll Chem & Mat Sci, Key Lab, Minist Educ Adv Catalysis Mat, Jinhua 321004, Zhejiang, Peoples R China

年份：2023

卷号：41

期号：21

起止页码：2825

外文期刊名：CHINESE JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001033884400001)，CCR-EXPANDED(收录号:WOS:001033884400001)】；

基金：Acknowledgement We are grateful for financial support from National Key Research and Development Program of China (2021YFA0804900), the NSFC (22171082, 21971062), the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang (No. 2022R01007), and Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism.

语种：英文

外文关键词：Pd-catalyzed; [4+4] cycloaddition; Homo-TMM 1; 4-dipoles; Methodology and reactions; Medium-ring compounds; Regioselectivity

摘要：We developed a novel Pd-catalyzed [4 + 4] cycloaddition of (benzo)furan-derived azadienes with homo-TMM all-carbon 1,4-dipoles in situ generated from a-allyl malonate derivatives, affording an array of benzofuro[3,2-b]azocines and furo[3,2-b]azocines with good to excellent yields (up to 96%) and exclusive regioselectivities. This methodology featured mild reaction conditions and good functional group tolerance. The synthetic utility was demonstrated by a gram-scale reaction. Furthermore, the catalytic asymmetric [4 + 4] cycloaddition version has also been explored.