文献类型：期刊文献

英文题名：Efficient synthesis of functionalized trifluoromethyl cyclopropanes via cyclopropanation of α-trifluoromethyl styrenes with chloroacetonitrile and ethyl chloroacetate

作者：Deng, Yupian[1];Liu, Ying[1];He, Jingjing[1];Zheng, Pai[1];Sun, Zhudi[1];Cao, Song[1,2]

机构：[1]East China Univ Sci & Technol ECUST, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

年份：2023

卷号：47

期号：35

起止页码：16604

外文期刊名：NEW JOURNAL OF CHEMISTRY

收录：;EI(收录号：20233614673697);WOS:【SCI-EXPANDED(收录号:WOS:001051366900001)，CCR-EXPANDED(收录号:WOS:001051366900001)】；

语种：英文

外文关键词：Column chromatography - Isomers - Propane

摘要：An efficient and practical method for the synthesis of functionalized trifluoromethyl cyclopropanes via cyclopropanation of & alpha;-trifluoromethyl styrenes with chloroacetonitrile or ethyl chloroacetate was developed. In some cases, the mixture of trans- and cis-isomers could be separated by column chromatography. The configurations of the trans-/cis-isomers were further confirmed by heteronuclear H-1-F-19 NOESY experiments.