文献类型：期刊文献

中文题名：Ring-restricted N-nitrosated rhodamine as a green-light triggered,orange-emission calibrated and fast-releasing nitric oxide donor

英文题名：Ring-restricted N-nitrosated rhodamine as a green-light triggered,orange-emission calibrated and fast-releasing nitric oxide donor

作者：Haihong He[2];Tingting He[2];Ziqian Zhang[3];Xiu Xu[2];Huibin Yang[4];Xuhong Qian[1,2];Youjun Yang[1,2]

机构：[1]State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China;[2]Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China;[3]Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China;[4]State Key Laboratory of the Discovery and Development of Novel Pestidde, Shenyang Sinochem Agrochemicals R&D Co., Ltd., Shenyang 110021, China

年份：2018

卷号：29

期号：10

起止页码：1497

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2017_2018】；

基金：financially supported by the National Natural Science Foundation of China (No. 21572061);the Fundamental Research Funds for the Central Universities (No. WY1516017)

语种：英文

中文关键词：NO donor;Photo-trigger;Photo-calibrate;Platelet aggregation inhibition;Antimicrobial

外文关键词：NO donor;Photo-trigger;Photo-calibrate;Platelet aggregation inhibition;Antimicrobial

摘要：Nitric oxide（NO） donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release.Inspired by this discovery, we developed a fast-releasing NO donor （NOD575） suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells（PASMCs）.
Nitric oxide（NO） donors are versatile tools for nitric oxide biology. The biological response of NO is dependent on the transient concentration and the sustained duration. N-Nitrosated rhodamines are photo-triggered and photo-calibrated NO donors. We recently discovered that suppression of the dihedral angle between the N-nitroso fragment with the rhodamine scaffold facilitates NO release.Inspired by this discovery, we developed a fast-releasing NO donor （NOD575） suitable for biological applications, e.g., the pulmonary arterial smooth muscle cells（PASMCs）.