文献类型：期刊文献

英文题名：Characterization of DNA duplex unzipping through a sub-2 nm solid-state nanopore

作者：Lin, Yao[1];Shi, Xin[1];Liu, Shao-Chuang[1];Ying, Yi-Lun[1];Li, Qiao[1];Gao, Rui[1];Fathi, Farkhondeh[2];Long, Yi-Tao[1];Tian, He[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Mt Allison Univ, Dept Chem & Biochem, 63C York St, Sackville, NB E4L 3G4, Canada

年份：2017

卷号：53

期号：25

起止页码：3539

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000399000100008)】；

基金：This work was supported by the National Natural Science Foundation of China (21505043, 21421004 and 21327807). Y.-L. Ying is supported by the 57th Chinese Post-doctor Fund (2016T90340).

语种：英文

摘要：Herein, the unzipping and translocation of DNA duplexes through a sub-2 nm silicon nitride (SiNx) solid-state nanopore have been demonstrated by well-resolved three-level blockades. In order to examine our observations, we applied a simple model which is applicable to the unzipping and translocation processes of DNA duplexes through solid-state nanopores. The generation of these highly recognizable signatures is an important step towards the real applications of solid-state nanopores in complex samples.