文献类型：期刊文献

英文题名：A Versatile Platform to Generate Shell-Cross-Linked Uniform Π-Conjugated Nanofibers with Controllable Length, High Morphological Stability, and Facile Surface Tailorability

作者：Wang, Chen[1];Huang, Fengfeng[1];Huang, Xiaoyu[1];Lu, Guolin[1];Feng, Chun[1,2]

机构：[1]Chinese Acad Sci, Univ Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet & Selfassembly Chem Organ Funct Mo, 345 Lingling Rd, Shanghai 200032, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Sch Mat Sci & Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2024

卷号：45

期号：2

外文期刊名：MACROMOLECULAR RAPID COMMUNICATIONS

收录：;EI(收录号：20234515036888);WOS:【SCI-EXPANDED(收录号:WOS:001101422500001)】；

基金：The authors are thankful for financial support from National Science Foundation for Distinguished Young Scholars (51825304), National Natural Science Foundation of China (52122314 and U22A20131), the project of Bureau of International Cooperation, CAS (121731KYSB20200006), Shanghai Scientific and Technological Innovation Project (21520780100, 21ZR1481700, 22JC1401000, and 22ZR1475400), Innovation Program of Shanghai Municipal Education Commission (2019-01-07-00-05-E00012), and East China University of Science and Technology. The authors thank Dr. Kun Cui for his assistance in TEM measurements.

语种：英文

外文关键词：living crystallization-driven self-assembly; nanofibers; self-seeding; thiol-ene chemistry; pi-conjugated block copolymers

摘要：Living crystallization-driven self-assembly (CDSA) has emerged as an efficient route to generate pi-conjugated-polymer-based nanofibers (CPNFs) with promising applications from photocatalysis to biomedicine. However, the lack of efficient tools to endow CPNFs with morphological stability and surface tailorability becomes a frustrating hindrance for expanding application spectrum of CPNFs. Herein, a facile strategy to fabricate length-controllable OPV-based (OPV = oligo(p-phenylenevinylene)) CPNFs containing a cross-linked shell with high morphological stability and facile surface tailorability through the combination of living CDSA and thiol-ene chemistry by using OPV5-b-PNAAM32 (PNAAM = poly(N-allyl acrylamide)) as a model is reported. Uniform fiber-like micelles with tunable length can be generated by self-seeding of living CDSA. By taking advantage of radical thiol-ene reaction between vinyls of PNAAM corona and four-arm thiols, the shell of micelles can be cross-linked with negligible destruction of structure of vinylene-containing OPV core. The resulting micelles show high morphological stability in NaCl solution and PBS buffer, even upon heating at 80 degree celsius. The introduced extra thiol groups in the cross-linked shell can be further employed to install extra functional moieties via convenient thiol-Michael-type reaction. Given the negligible cytotoxicity of resulting CPNFs, this strategy opens an avenue to fabricate various CPNFs of diverse functionalities for biomedicine.