文献类型：期刊文献

中文题名：Janus γ-Fe2O3/SiO2-based nanotheranostics for dual-modal imaging and enhanced synergistic cancer starvation/chemodynamic therapy

英文题名：基于双面(Janus)γ-Fe2O3/SiO2的纳米诊疗剂用于双模态成像和增强型癌症饥饿/化学动力学协同治疗

作者：Yifan Zhang[1];Yilin Wan[1];Yunyan Liao[1];Yanjie Hu[3];Tao Jiang[2];Ting He[1];Wei Bi[3];Jing Lin[1];Peng Gong[4];Longhua Tang[2];Peng Huang[1]

机构：[1]Marshall Laboratory of Biomedical Engineering,International Cancer Center,Laboratory of Evolutionary Theranostics(LET),School of Biomedical Engineering,Shenzhen University Health Science Center,Shenzhen 518060,China;[2]State Key Laboratory of Modern Optical Instrumentation,College of Optical Science and Engineering,Zhejiang University,Hangzhou 310027,China;[3]Key Laboratory for Ultrafine Materials of Ministry of Education,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai 200237,China;[4]Department of General Surgery,Shenzhen University General Hospital,Shenzhen 518055,China

年份：2020

卷号：65

期号：7

起止页码：564

中文期刊名：Science Bulletin

外文期刊名：科学通报（英文版）

收录：Scopus;CSCD:【CSCD2019_2020】；PubMed;

基金：This work was supported by the National Key Research and Development Program of China(2018YFA0704003);the Basic Research Program of Shenzhen(JCYJ20180305163452667,JCYJ20180507182413022,and JCYJ20170412111100742);the National Natural Science Foundation of China(81903564,31771036,51703132,and 21874119);the Guangdong Provincial Natural Science Foundation of Major Basic Research and Cultivation Project(2018B030308003);the Fok Ying-Tong Education Foundation for Young Teachers in the Higher Education Institutions of China(161032);We thank Instrumental Analysis Center of Shenzhen University(Lihu Campus).

语种：英文

中文关键词：Synergistic therapy;Janus nanoparticles;Glucose oxidase;Fenton-like reaction;Theranostics

外文关键词：协同治疗;肿瘤微环境;化学动力学;磁共振成像;治疗功效;歧化作用;葡萄糖氧化酶;羟基自由基

摘要：Multimodal cancer synergistic therapy exhibited remarkable advantages over monotherapy in producing an improved therapeutic efficacy. In this work, Janus-type γ-Fe2 O3/SiO2 nanoparticles(JFSNs) are conjugated with glucose oxidase(GOx) for synergistic cancer starvation/chemodynamic therapy. The γ-Fe2O3 hemisphere of JFSNs can perform photoacoustic/T2 magnetic resonance dual-modal imaging of tumors.GOx on the surface of JFSNs catalyzes the decomposition of glucose and produces H2O2 for cancer starvation therapy. Subsequently, the γ-Fe2O3 hemisphere catalyzes the disproportionation of H2O2 to generate highly reactive hydroxyl radicals in an acidic tumor microenvironment. The close distance between GOx and JFSNs ensures adequate contact between the γ-Fe2O3 hemisphere and its substrate H2O2, thus enhancing the catalytic efficiency. This synergy of glucose depletion, biotoxic H2O2 and hydroxyl radicals significantly suppresses 4 T1 mammary tumor growth with minimal adverse effects.
与单模式治疗相比,多模式癌症协同治疗展现出显著的优势,产生提高的治疗功效.本文研究葡萄糖氧化酶(GOx)偶联的双面型γ-Fe2O3/SiO2纳米粒子(JFSNs)用于癌症饥饿/化学动力学协同治疗. JFSNs的γ-Fe2O3半球可以用于肿瘤的光声/T2磁共振成像;JFSNs表面的GOx可以催化葡萄糖的分解而产生H2O2用于癌症饥饿治疗.γ-Fe2O3半球在酸性肿瘤微环境中催化H2O2发生歧化作用产生高反应活性的羟基自由基. GOx与JFSNs距离极短,从而确保了γ-Fe2O3半球与其反应底物H2O2的充分接触.葡萄糖的消耗、有生物毒性的H2O2和羟基自由基三者协同能够显著抑制4T1乳腺癌肿瘤的生长,同时具有极低的副作用.