文献类型：期刊文献

英文题名：Cross-Linked PEG via Degradable Phosphate Ester Bond: Synthesis, Water-Swelling, and Application as Drug Carrier

作者：Liu, Zhaoxing[1,2,3];Wang, Lei[1,2,3];Bao, Chunyan[1,2,3];Li, Xinxin[4];Cao, Lei[5];Dai, Kerong[5];Zhu, Linyong[1,2,3]

机构：[1]E China Univ Sci & Technol, Inst Fine Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Key Lab Specially Funct Polymers, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Related Technol Minist Educ, Shanghai 200237, Peoples R China;[4]E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[5]Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Shanghai Key Lab Orthopaed Implant,Dept Orthopaed, Shanghai 200011, Peoples R China

年份：2011

卷号：12

期号：6

起止页码：2389

外文期刊名：BIOMACROMOLECULES

收录：;EI(收录号：20112514074380);WOS:【SCI-EXPANDED(收录号:WOS:000291499900052)】；

基金：We thank the NSFC (20903039, 21073062), "Chen Guang" project (09CG25), Shanghai Rising-star Program (10QA1401600), and Shanghai Sci. Tech. Comm. (09ZR1408600) for financial support.

语种：英文

外文关键词：Crosslinking - Targeted drug delivery - Ethers - Biological materials - Controlled drug delivery - Esters - Polyethylenes - Degradation

摘要：A new series of degradable and water-swellable cross-linked PEG phosphoester polymers (CPPs) based on a facile cross-linked reaction between diphosphoesters of polyethylene glycol (P-PEG-P) and diglycidyl ether of polyethylene glycol (E-PEG-E) has been prepared and characterized. The molecular weights and ratios of the prepolymers played an important role for the properties of CPPs polymers, such as mechanical property, swelling, and degradation rates. In the curing process, the glycidyl ether was consumed by both hydroxyl of the phosphoester (P-OH) and hydroxyl generated from the opened glycidyl ethers (C-OH) with the presence of acid, which generated degradable phosphate esters as cross-linked points and ether bonds as the short branches, respectively. Drug entrapment and release test and biological cytotoxicity studies in vitro suggested that the polymers and generated hydrogels have great potential applications in drug delivery system and biological materials.