文献类型：期刊文献

中文题名：Precise phase adjustment and antibacterial property of copper sulfide particles in confined mesoporous silica nanoreactor

作者：Shiyu Xu[1];Jinyong Wu[1];Zhongzhen Ren[1];Dechao Niu[1]

机构：[1]Low Dimensional Materials Chemistry Laboratory,Key Laboratory for Ultrafine Materials of Ministry of Education,Frontier Science Center of the Materials Biology and Dynamic Chemistry,Shanghai Engineering Research Center of Hierarchical Nanomaterials,School of Materials Science and Engineering,East China University of Science and Technology,Shanghai,200237,China

年份：2024

卷号：85

期号：2

起止页码：113

中文期刊名：Particuology

外文期刊名：颗粒学报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2023_2024】；PubMed;

基金：supported by the National Natural Science Foundation of China(grant No.52072124 and 51972112);Natural Science Foundation of Shanghai(grant No.20zR1414900);Program of Shanghai Academic/Technology Research Leader(grant No.22XD1421100);The Fundamental Research Funds for the Central Universities,and the 111 project(grant No.B14018).

语种：英文

中文关键词：Copper sulfides;Mesoporous silica;Photothermal;Reactive oxygen species;Antibacterial agent

摘要：Bacteria-caused wound infection greatly threatens human health,thus developing an efficient and safe antibacterial agent without drug resistance is still a great challenge.Herein,a confined vulcanization strategy is proposed to construct copper sulfides-loaded dual-mesoporous silica nanospheres(Cux-Sy@DMSNs)with various crystal phases for reactive oxygen species(ROS)-mediated and photothermal antibacterial application.With the pore confinement of DMSNs,the crystal phases of copper sulfides including CuS,Cu_(9)S_(5)and Cui.96S can be easily controlled by changing the vulcanization temperature.The relationships between the crystal phases and photothermal properties as well as peroxidase-like activity of copper sulfides were systematically investigated.Results show that the obtained CuS@DMSNs exhibited higher photothermal ability with remarkable photothermal conversion efficiency of 36.86%in the second near-infrared region(NIR-II)and better peroxidase-like activity,compared to those of Cu_(9)S_(5)@DMSNs and Cu_(1.96)S@DMSNs.As a result,the in vitro experiments showed the good antibacterial effect against both gram-negative E.coli and gram-positive S.aureus under 1064 nm laser irradiation and the presence of H_(2)O_(2).Besides,the CCK-8 assay indicated that CuS@p-DMSNs have minimal cytotoxicity against normal human umbilical vein endothelial cells at the ranged concentrations.Therefore,the resultant CuS@p-DMSNs could act as a promising antibacterial agent for deep wound bacterial infection treatment.