文献类型：期刊文献

英文题名：Near-Infrared Light-Controlled Nitric Oxide Delivery Combined with In Situ Activated Chemotherapy for Enhanced Multimodal Therapy

作者：Ren, Bing[1];Liu, Jing[1];Wang, Yi[2];Tang, Qi[1];Fang, Jian[1];Yang, Shiping[3,4];Liu, Jin-Gang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen Key Lab Funct Polymer, Shenzhen 518060, Peoples R China;[3]Shanghai Normal Univ, Key Lab Resource Chem MOE, Shanghai 200234, Peoples R China;[4]Shanghai Normal Univ, Shanghai Key Lab Rare Earth Funct Mat, Shanghai 200234, Peoples R China

年份：2025

卷号：8

期号：4

起止页码：3431

外文期刊名：ACS APPLIED BIO MATERIALS

收录：EI(收录号：20251518219439);WOS:【ESCI(收录号:WOS:001461972100001)】；

基金：This study was financially supported by the National Natural Science Foundation of China (No. 21571062), the Program for Professor of Special Appointment (Eastern Scholar) at the Shanghai Institutions of Higher Learning, and the Fundamental Research Funds for the Central Universities (No. 222201717003).

语种：英文

外文关键词：copper complex; in situ activation; chemotherapy; nitric oxide release; gas therapy; nanomedicine

摘要：Development of nanoplatforms with in situ activation for chemotherapy represents a promising modality for biomedical application. Herein, a multifunctional nanoplatform, CMS@DTC@PDA@RuNO@FA (abbreviated as CDPNF NPs), was developed for highly efficient antitumor therapy, in which diethyldithiocarbamate (DTC)-loaded mesoporous Cu2MoS4 (CMS) nanoparticles were covered by polydopamine (PDA) layers and further covalently modified with a NO donor (RuNO) and a folic acid (FA)-directing moiety. Under the mild acidic tumor microenvironment (TME), the CDPNF NPs co-liberated DTC and Cu2+ in the tumor site, where in situ formation of the highly cytotoxic Cu(DTC)2 complex effectively killed tumor cells. Furthermore, under near-infrared (NIR) light irradiation, the CDPNF NPs could deliver nitric oxide (NO) and produce superoxide anions (O2 center dot-), followed by the formation of more toxic peroxynitrite (ONOO-), which led to promoted cell apoptosis. Under 1064 nm NIR light irradiation, in vivo experiments with CDPNF NPs demonstrated an impressively high tumor inhibition rate (similar to 97%) while with good biocompatibility. This work represents an in situ activated approach for precision medicine that might imply its promising potential for clinical applications.