文献类型：期刊文献

英文题名：The effect of polymer-surfactant emulsifying agent on the formation and stability of α-lipoic acid loaded nanostructured lipid carriers (NLC)

作者：Zheng, Kai[1,2,5];Zou, Aihua[1,2];Yang, Xiaomin[1,2];Liu, Fang[1,2];Xia, Qiang[3,4];Ye, Ruqiang[1,2];Mu, Bozhong[1,2]

机构：[1]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Inst Appl Chem, Shanghai 200237, Peoples R China;[3]Southeast Univ, Sch Biol Sci & Med Engn, Sipai Lou 210096, Nanjng, Peoples R China;[4]Southeast Univ, Suzhou Key Lab Biomed Mat & Technol, Suzhou 215123, Peoples R China;[5]Jala Grp Co, R&D Ctr, Shanghai 200233, Peoples R China

年份：2013

卷号：32

期号：1

起止页码：72

外文期刊名：FOOD HYDROCOLLOIDS

收录：;EI(收录号：20233214515707);WOS:【SCI-EXPANDED(收录号:WOS:000314852600009)】；

基金：This work was supported by Chinese National Natural Science Foundation (201003047), Fundamental Research Funds for the Central Universities (WK1014024) and International Cooperation Project of the Ministry of Science and Technology of PRC (2008DFB50060).

语种：英文

外文关键词：Nanostructured lipid carriers; alpha-Lipoic acid; Emulsifying agent; High pressure homogenization; Food solution

摘要：alpha-Lipoic acid loaded nanostructured lipid carriers (ALA-NLC) were developed by high pressure homogenization (HPH) technology. The effects of polymer-surfactant emulsifying agents on the formation and stability of ALA-NLC were characterized by dynamic light scattering (DLS), rheological analysis, wide angle X-ray diffraction (WAXD), and high efficiency liquid chromatography (HPLC). The particles size, viscoelastic property and stability of ALA-NLC samples were significantly influenced by polymer -surfactant emulsifying agents. Polymer is considered as a primary emulsifying agent in ALA-NLC. Surfactants, which have small and flexible hydrophilic head group, would have strong interaction with polymer, and form strong interfacial film, thus could improve the stability of ALA-NLC. These results will be productive for better understanding of the preparation and stability of NLC, and two formulations applied here may have some potential applications for alpha-lipoic acid dietary supplement or nutri-cosmetics. (c) 2012 Elsevier Ltd. All rights reserved.