文献类型：期刊文献

英文题名：Advances in super-resolution fluorescence microscopy for the study of nano-cell interactions

作者：Chen, Xi[1];Wang, Yu[2];Zhang, Xuewei[1];Liu, Changsheng[1]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ,Sch Mat Sci & Engn, Frontiers Sci Ctr Materiobiol & Dynam Chem,Engn R, Shanghai 200237, Peoples R China;[2]Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA

年份：2021

卷号：9

期号：16

起止页码：5444

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20213410805552);WOS:【SCI-EXPANDED(收录号:WOS:000674775900001)】；

基金：This work was primarily supported by the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002), the National Key R&D Program of China (No. 2018YFC1105700), and the Fundamental Research Funds for the Central Universities (No. JKVD12001002). Y. W. was not supported by this funding. We acknowledge Prof. Frank Caruso (The University of Melbourne), Mr Thomas Ferrante (Harvard University), and Mr Dongyong Sha (East China University of Science and Technology) for their helpful discussions. Any opinions, findings, conclusions, or recommendations expressed herein are those of the author(s).

语种：英文

外文关键词：Fluorescence - Optical resolving power - Nanostructured materials

摘要：Understanding the interactions between nanomaterials and biological systems plays an essential role in enhancing the efficacy of nanomedicines and deepening the understanding of the biological domain. Fluorescence microscopy is a powerful optical imaging technique that allows direct visualization of the behavior of fluorescent-labeled nanomaterials in the intracellular microenvironment. However, conventional fluorescence microscopy, such as confocal microscopy, has limited optical resolution due to the diffraction of light and therefore cannot provide the precise details of nanomaterials with diameters of less than similar to 250 nm. Fortunately, the development of super-resolution fluorescence microscopy has overcome the resolution limitation, enabling more comprehensive studies of nano-cell interactions. Herein, we have summarized the recent advances in nano-cell interactions investigated by a variety of super-resolution microscopic techniques, which may benefit researchers in this multi-disciplinary area by providing a guideline to select appropriate platforms for studying materiobiology.