文献类型：期刊文献

英文题名：Characterization of tissue responses and degradation behavior of heparin-immobilized copolymer for drug-eluting stents

作者：Shen, Li[1];Li, Zhenru[2];Gong, Feirong[3];Zhang, Feng[1];Qin, Qing[1];Cheng, Shujun[3];Ge, Junbo[1]

机构：[1]Fudan Univ, Zhongshan Hosp, Shanghai Inst Cardiovasc Dis, Shanghai 200032, Peoples R China;[2]Peoples Hosp Shanghai Putuo Dist, Dept Cardiol, Shanghai 200030, Peoples R China;[3]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China

年份：2013

卷号：98

期号：5

起止页码：1015

外文期刊名：POLYMER DEGRADATION AND STABILITY

收录：;EI(收录号：20131516199461);WOS:【SCI-EXPANDED(收录号:WOS:000318379200012)】；

基金：This work was supported by a grant from the National Basic Research Program of China (No. 2011CB503905) from the Ministry of Science and Technology of China, the Science and Technology Commission of Shanghai, China (No.11nm0504900, 12DZ1940604), National Natural Science Foundation of China (No. 81101133, 81000044), the Shanghai Outstanding Young Scientist Project from the Shanghai Municipal Health Bureau, the Young Scientific 'Phosphor' (Tracking) Project from the Shanghai Science and Technology Development (No. 11QH1400500).

语种：英文

外文关键词：Stent; Coating; Biodegradable; Tissue response

摘要：It has been hypothesized that persistent presence of polymeric coating material may compromise the safety for drug-eluting stents, and that therefore a biodegradable coating might reduce late adverse events. In the present study, we explored the degradation behavior of heparin-immobilized copolymer of L-lactide (LA) and 5-methyl-5-benzyloxycarbonate-1,3-dioxan-2-one (MBC) coated stents and cast films by gel permeation chromatography (GPC), weight loss, light microscope, scanning electron microscope (SEM), and immunohistochemical staining in vitro and in vivo. The in vitro data indicated that the casting films lost 80% molecular weight and 20% of its mass within 16 weeks in PBS. The complete degradation of the coating material on the stent surface occurred within 16 weeks. The study also demonstrated similar degradation behaviors of the coating material in vivo conditions. There was no significant difference in extensive endothelialization and expression of inflammation-associated proteins such as monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), and CD3 after 4 weeks post stent implantation. So the heparin-immobilized copolymer is an excellent candidate material for drug-eluting stents given its lack of permanent existence after drug release and minimal in vivo tissue responses. (C) 2013 Elsevier Ltd. All rights reserved.