文献类型：期刊文献

英文题名：Preparation and characterization of antibacterial polyvinyl alcohol/chitosan sponge and potential applied for wound dressing

作者：Fan, Yao[1];Lu, Qiaohui[2];Liang, Wencheng[1];Wang, Youchang[1];Zhou, Yan[2];Lang, Meidong[1]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2021

卷号：157

外文期刊名：EUROPEAN POLYMER JOURNAL

收录：;EI(收录号：20213110713679);WOS:【SCI-EXPANDED(收录号:WOS:000693338800006)】；

基金：This research was supported by the National Key Research and Development Program (2016YFC1100703) .

语种：英文

外文关键词：PVA; DMAEMA; Chitosan; Wound dressing; Antibacterial

摘要：In this work, polyvinyl alcohol (PVA) with antimicrobial properties (QPVD), which were modified by 2(Dimethylamino)ethyl methacrylate (DMAEMA) and 1-bromobutane. QPVD/chitosan (CS) composite sponge dressing (QPVDC) were prepared using freeze-drying process and cross-linked with glutaraldehyde vapor. Interestingly, compared with CS wound dressing, water absorption and flexibility of QPVDC wound dressing could be significantly improved with QPVD introduced. Among them, the water absorption of QPVDC sponge was up to 2300% and the elongation at break increased by 40-113%. In addition, QPVDC sponges with more quaternary ammonium could improve higher antibacterial activity, and the highest antibacterial activity of QPVDC sponges was close to 100% against E. coli and S. aureus. The results of hemolysis and cytotoxicity in vitro indicated that QPVDC wound dressing had excellent hemocompatibility and cytocompatibility. In summary, QPVDC wound dressing could protect from bacterial infection and accelerate wound healing. Thus, QPVDC had high potential application value for wound dressing.