文献类型：期刊文献

英文题名：Ionic liquids as effective additives to enhance the solubility and permeation for puerarin and ferulic acid

作者：Yuan, Jing[1];Zhou, Ningning[2];Wu, Jieyu[2];Yin, Tianxiang[2];Jia, Yunbin[1]

机构：[1]Shanghai Sixth Peoples Hosp, Shanghai 201306, Peoples R China;[2]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2022

卷号：12

期号：6

起止页码：3416

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20220511578730);WOS:【SCI-EXPANDED(收录号:WOS:000746909800001)】；

基金：This work was supported by the National Natural Science Foundation of China (Projects 21773063). The author Jing Yuan also thanks for the financial support from the scientific research project in Shanghai Sixth People's Hospital.

语种：英文

外文关键词：Solubility - Controlled drug delivery - Targeted drug delivery

摘要：Ionic liquids, especially the cholinium-amino acid-based ionic liquids (CHAAILs), have recently been found to be effective ingredients in formulation of transdermal drug delivery system. In this work, we synthesized six CHAAILs, and investigated their ability to enhance the solubility and permeation of two active pharmaceutic ingredients (APIs), i.e. ferulic acid and puerarin. The solubility measurements showed that a low amount of CHAAILs can significantly increase the solubility of APIs. Moreover, the effective enhancement of permeation of APIs across a polyethersulfone (PES) membrane was achieved at low concentration (4 mg ml(-1)) of CHAAILs. It is more worthwhile that the presence of CHAAIL brings much less cytotoxicity as compared to traditional types of ionic liquids. Therefore, CHAAILs can be considered as great potential candidates of green and effective additives in transdermal drug delivery systems.