文献类型：期刊文献

英文题名：Noncatalytic Pyridyl-Directed Alkylation and Arylation Carbon-Fluorine Bond of Polyfluoroarenes with Grignard Reagents

作者：Xiong, Yang[1];Wu, Jingjing[1,2];Xiao, Senhan[1];Xiao, Juan[1];Cao, Song[1,2]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

年份：2013

卷号：78

期号：9

起止页码：4599

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20131916321481);WOS:【SCI-EXPANDED(收录号:WOS:000318588800045)，CCR-EXPANDED(收录号:WOS:000318588800045)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (Grant Nos. 21072057 and 21272070), the Key Project in the National Science & Technology Pillar Program of China in the twelfth five-year plan period (2011BAE06B01-15), and the 973 Program (2010CB126101).

语种：英文

外文关键词：Fluorine - Carbon - Chemical reactions

摘要：Cross-coupling reaction of polyfluoroarenes with Grignard reagents via pyridine-directed cleavage of C-F bond in the absence of metal catalysts was developed. A possible mechanism was suggested.