文献类型：期刊文献

英文题名：Ligand-Boosted Copper Catalysis for Air-Tolerant Methoxylation of (Hetero)aryl Halides With Sodium Methoxide

作者：Xu, Ke[1];Wu, Shigang[1];Zou, Gang[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai, Peoples R China

年份：2024

卷号：38

期号：12

外文期刊名：APPLIED ORGANOMETALLIC CHEMISTRY

收录：;EI(收录号：20243416917380);WOS:【SCI-EXPANDED(收录号:WOS:001294643300001)】；

语种：英文

外文关键词：anisoles; aryl halides; bipyridine; copper catalysis; methoxylation

摘要：An air-tolerant, simple yet highly efficient copper-catalyzed methoxylation of (hetero)aryl bromides and some activated chlorides has been developed by using copper(II) chloride/2,2-bipyridine as catalyst precursor. A wide range of (hetero)aryl bromides and electron-deficient chlorides could be efficiently methoxylated in good to excellent yields at 1-mol% catalyst loading albeit showing a functional group compatibility dependent on the electronic properties of aryl ring. Applications of the practical protocol have been demonstrated in multigram synthesis of 3,4,5-trimethoxytoluene.