文献类型：期刊文献

中文题名：手性芳基邻二醇的不对称合成

英文题名：Asymmetric Synthesis of Chiral Aryl Vicinal Diols

作者：刘湘[1];潘争光[1];许建和[2]

机构：[1]江南大学化学与材料工程学院,无锡214122;[2]华东理工大学生物反应器工程国家重点实验室,上海200237

年份：2011

卷号：23

期号：5

起止页码：903

中文期刊名：化学进展

外文期刊名：Progress in Chemistry

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000293038300009)】；北大核心:【北大核心2008】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金项目(No.20672037);国家重点实验室专项经费(No.2060204)资助

语种：中文

中文关键词：手性芳基邻二醇;不对称合成;生物催化;化学催化

外文关键词：chiral aryl vicinal diols; asymmetric synthesis; biocatalysis; chemocatalysis

摘要：具有特定功能基团的手性芳基邻二醇是许多具有特殊功能的药物、农药和信息素的重要中间体,近年来手性芳基邻二醇类化合物的合成与应用研究引起了人们的广泛关注。本文从生物催化不对称合成和化学催化不对称合成两方面综述了近年来手性芳基邻二醇的合成进展,概述了前手性底物上取代基的电子效应和空间效应、手性催化剂的种类和反应体系等因素对合成手性芳基邻二醇产率及光学活性的影响,并对手性芳基邻二醇不对称合成的发展趋势进行了展望。
Chiral aryl vicinal diols with special functional group are potentially valuable synthetic intermediates for the preparation of pharmaceuticals,agrochemicals and pheromones.In recent years,the synthesis and application of chiral aryl vicinal diols have attracted intensive attention of chemists.Recent progress in asymmetric synthesis of chiral aryl vicinal diols is reviewed in both biocatalytic and chemocatalytic perspectives.The effects of some factors,including the electronic effects and steric factors of substituted groups,the species of chiral catalysts and the different reaction media,on the yields and optical activity of chiral aryl vicinal diols are summarized.The trends in the asymmetric synthesis of chiral aryl vicinal diols are prospected.