文献类型：期刊文献

英文题名：Biodegradable organosilica magnetic micelles for magnetically targeted MRI and GSH-triggered tumor chemotherapy

作者：Yang, Tiangang[1];Niu, Dechao[1];Chen, Jianzhuang[1];He, Jianping[1];Yang, Shaobo[1];Jia, Xiaobo[1];Hao, Jina[1];Zhao, Wenru[1];Li, Yongsheng[1]

机构：[1]East China Univ Sci & Technol, Lab Low Dimens Mat Chem, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China

年份：2019

卷号：7

期号：7

起止页码：2951

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20192607117754);WOS:【SCI-EXPANDED(收录号:WOS:000474601400023)】；

基金：This work was financially supported by the National Key Research and Development Program of China (Grant No. 2018YFC1105702 and 2016YFA0203700); the National Natural Science Foundation of China for Innovative Research Groups (No. 51621002); NSFC (Grant No. 51572083); Program of Shanghai Academic/Technology Research Leader (18XD1401400); Basic Research Program of Shanghai (17JC1404702); Leading talents in Shanghai in 2018; the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning; the 111 project (B14018) and the Fundamental Research Funds for Central Universities (222201718002).

语种：英文

外文关键词：Silica - Amino acids - Micelles - Medical applications - Tumors - Block copolymers - Targeted drug delivery - Biodegradability - Controlled drug delivery - Magnetite - Magnetic resonance imaging - Self assembly

摘要：Recently, block copolymer micelles have attracted widespread attention due to their controlled biodegradability and excellent loading capability. Unfortunately, the poor in vivo stability and low delivery efficiency of drug-loaded micelles greatly hampered their biomedical applications. Herein, we develop a new kind of biodegradable magnetite/doxorubicin (Fe3O4/DOX) co-loaded PEGylated organosilica micelles (designated as FDPOMs) with both high circulating stability and smart GSH-triggered biodegradability for magnetically targeted magnetic resonance imaging (MRI) and tumor chemotherapy. The FDPOMs are prepared by the self-assembly of biodegradable polycaprolactone-block-poly(glutamic acid) (PCL-b-PGA), a chemotherapeutic DOX drug and Fe3O4 nanoparticles in an oil/water system, subsequent organosilica cross-linking with 3-mercaptopropyltrimethoxysilane (MPTMS) molecules and surface PEGylation. The resultant FDPOMs exhibit excellent dispersity and stability in biological media, remarkable T-2-weighted MR imaging capability, unique GSH-responsive release behavior and selective toxicity to tumor cells. The in vivo experiments show that the FDPOMs not only have improved MR tumor imaging capability, but also exhibit high anti-tumor efficacy due to the strong magnetic targeting ability under an external magnetic field. Consequently, the FDPOMs are promising candidates for magnetically targeted MR imaging and imaging-guided tumor chemotherapy.