文献类型：期刊文献

英文题名：A review of radiofrequency ablation: Large target tissue necrosis and mathematical modelling

作者：Zhang, Bing[1,2];Moser, Michael A. J.[3];Zhang, Edwin M.[4];Luo, Yigang[3];Liu, Changli[1];Zhang, Wenjun[1,2,5]

机构：[1]East China Univ Sci & Technol, Sch Mech & Power Engn, Complex & Intelligent Syst Ctr, Shanghai 200237, Peoples R China;[2]Univ Saskatchewan, Div Biomed Engn, Saskatoon, SK S7N 5A9, Canada;[3]Univ Saskatchewan, Dept Surg, Saskatoon, SK S7N 0W8, Canada;[4]Univ Toronto, Div Vasc & Intervent Radiol, Dept Med Imaging, Toronto, ON M5T 1W7, Canada;[5]Univ Saskatchewan, Dept Mech Engn, Saskatoon, SK S7N 5A9, Canada

年份：2016

卷号：32

期号：8

起止页码：961

外文期刊名：PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000381588600001)】；

基金：This article was supported by the Saskatchewan Health Research Foundation (SHRF) through the 'BioNEMS Phase I' grant and the National Natural Science Foundation of China (grant no. 51175179). The first author (Bing Zhang) also received financial support from the China Scholarship Council (CSC) for this research.

语种：英文

外文关键词：Clinical results; Mathematical modelling; Radiofrequency ablation; Target tissue necrosis

摘要：Radiofrequency ablation (RFA) is an effective clinical method for tumour ablation with minimum intrusiveness. However, the use of RFA is mostly restricted to small tumours, especially those <3 cm in diameter. This paper discusses the state-of-the-art of RFA, drawn from experimental and clinical results, for large tumours (i.e. >= 3 cm in diameter). In particular, the paper analyses clinical results related to target tissue necrosis (TTN) and mathematical modelling of the RFA procedure to understand the mechanism whereby the TTN is limited to under 3 cm with RFA. This paper also discusses a strategy of controlling of the temperature of target tissue in the RFA procedure with the state-of-art device, which has the potential to increase the size of TTN. This paper ends with a discussion of some future ideas to solve the so-called 3-cm problem with RFA. (C) 2016 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.