文献类型：期刊文献

英文题名：Algae-Integrated Optoelectronic Nanoplatform for Tumor Hypoxia Relief and Enhanced Photodynamic Therapy

作者：Ma, Gongcheng[1];Zhang, Nan[1,2];Shi, Hongrong[1];Li, Yaoqiang[1];Wang, Haoran[3,4];Tang, Chaoyang[1];Wang, Shengmei[3];Chen, Hongli[1];Wang, Qingzhi[1];Wang, Zhaohui[5,6];Liu, Guogang[5];Tang, Ben Zhong[4];Ding, Qihang[2]

机构：[1]Xinxiang Med Univ, Nanobiomed Mat Res Ctr, Sch Life Sci & Technol, Xinxiang Key Lab Biomed Mat, Xinxiang, Peoples R China;[2]Korea Univ, Dept Chem, Seoul, South Korea;[3]Shenzhen MSU BIT Univ, Fac Mat Sci, Shenzhen, Peoples R China;[4]Chinese Univ Hong Kong Shenzhen, Guangdong Basic Res Ctr Excellence Aggregate Sci, Sch Sci & Engn, Shenzhen, Guangdong, Peoples R China;[5]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, Shanghai, Peoples R China;[6]Tsinghua Univ, Dept Chem, Key Lab Organ Optoelect & Mol Engn, Beijing, Peoples R China

年份：2026

外文期刊名：ADVANCED HEALTHCARE MATERIALS

收录：;EI(收录号：20263321326230);Scopus(收录号：2-s2.0-105047491383);WOS:【SCI-EXPANDED(收录号:WOS:001849954800001)】；

基金：G. M. and N. Z. contributed equally to this work. This work was supported by the National Natural Science Foundation of China (52403206, 22401094), the Program for The Doctoral Scientific Research Foundation of Xinxiang Medical University (300/505541), the Natural Science Foundation of Shanghai (No. 24ZR1416100), the China Scholarship Council (CSC, 202106270027), Shenzhen Medical Research Fund (A2503075), Shenzhen Science and Technology Program (JCYJ20250604173216021), Guangdong Province University Innovation Team Program (2025KCXTD054), the Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, Guangzhou 510640, China (South China University of Technology)'' (2023B1212060003), Guangdong Province Project (ZJQNRC20241219163127014).

语种：英文

外文关键词：algae; pentaperylene decaimides; photodynamic therapy; photosensitizer; tumor hypoxia

摘要：The clinical efficacy of photodynamic therapy (PDT) is fundamentally limited by the scarcity of efficient photosensitizers (PSs) and the oxygen dependence of singlet-oxygen-mediated cytotoxicity. Here we report pentaperylene decaimide selenide (PPD-Se), a nanographene-derived photoelectronic material that functions as a high-performance Type-II photosensitizer. PPD-Se exhibits broadband absorption (300-650 nm), enhanced intersystem crossing enabled by a selenium-induced heavy-atom effect, a small Delta E ST (0.50 eV), and a high 1O2 quantum yield (Phi Delta = 0.40). To address hypoxia-limited PDT, PPD-Se nanoparticles were covalently integrated with microalgae to construct an algae@PPD-Se biohybrid, in which PPD-Se is shielded from premature activation yet undergoes glutathione (GSH)-triggered release in the tumor microenvironment. Cleavage of disulfide linkages restores the photosynthetic activity of algae, enabling light-driven O2 production that alleviates local hypoxia and simultaneously boosts PPD-Se-mediated ROS generation. The biohybrid exhibits enhanced intracellular uptake, amplified ROS production, and potent apoptosis induction under white light-emitting diode (LED) irradiation (400-700 nm, 1 mW & centerdot;cm-2). In vivo, algae@PPD-Se significantly downregulates HIF-1 alpha, restores intra-tumoral oxygenation, and achieves marked tumor growth inhibition without observable systemic toxicity. This study introduces a dual-functional optoelectronic-biological PDT platform that couples a newly designed nanographene photosensitizer with photosynthetic oxygenation, offering a mechanistically driven strategy to overcome the oxygen dependency of PDT.