文献类型：期刊文献

中文题名：负载硫化铋纳米簇的硅基杂化胶束的制备及其光热抗菌性能

英文题名：Bismuth Sulfide Nanoclusters-loaded Silica-based Hybrid Micelles:Preparation and Photothermal Antibacterial Property

作者：赵丽华[1];王言帅[1];尹昕妩[1];毛叶琼[1];牛德超[1]

机构：[1]华东理工大学材料科学与工程学院,上海200237

年份：2025

卷号：40

期号：10

起止页码：1129

中文期刊名：无机材料学报

外文期刊名：Journal of Inorganic Materials

收录：;EI(收录号：20254119282399);WOS:【SCI-EXPANDED(收录号:WOS:001606029900006)】；北大核心:【北大核心2023】；

基金：National Natural Science Foundation of China (32371406) ; Program of Shanghai Academic/Technology Research Leader (22XD1421100)

语种：中文

中文关键词：氧化硅;嵌段共聚物;硫化铋;光热性能;抗菌剂

外文关键词：silicon oxide;block copolymer;bismuth sulfide;photothermal property;antibacterial agent

摘要：铋基纳米材料作为一种新型光热试剂,具有毒性低、环境友好、原料廉价易得等优势,在生物光热治疗方面展示出较大的应用潜力,但其光热转换效率和抗菌性能仍然较低。本研究首先基于课题组前期报道的“限域凝胶化”方法,以普朗尼克聚合物F127和3-巯基丙基-三甲氧硅烷为原料,制备了有机硅氧骨架稳定胶束内核的硅基杂化胶束前驱体,然后通过简便的“受限还原/硫化”方法,即利用杂化胶束有机氧化硅网络内核中丰富的巯基基团作为受限吸附位点,硼氢化钠作为还原剂,硫化钠作为硫化剂,制备了超小且具有无定形结构的硫化铋团簇负载的硅基杂化胶束体系。结果表明,该功能杂化胶束体系具有优异的光热性能,其光热转换效率高达86.93%,这归因于具有缺陷结构的硫化铋团簇在硅氧骨架网络中的单分散稳定负载,增强了硫化铋纳米材料在近红外光波段的光吸收能力。体外抗菌实验结果表明,该体系在808 nm近红外光的辐照下展示出优异的光热抗菌性能且具有良好的生物相容性。
As a new type of photothermal compound,bismuth-based nanomaterials have advantages of low toxicity,environmental friendliness,and cheap raw materials,showing great application potential in biological photothermal therapy,but their photothermal conversion efficiency and antibacterial property are still low.In this study,based on the confined gelation method reported by previous literature,a silica-based hybrid micellar precursor with organosilica-stabilized micellar cores was prepared using Pluronic polymer F127 and 3-mercaptopropyl-trimethoxy-silane as raw materials,and a facile“confined reduction/sulfuration”method was further developed,that is,the abundant thiol groups in the organosilica framework of the micelle core were used as restricted adsorption sites,sodium borohydride was used as reducing agent,and sodium sulfide was used as vulcanizing agent to prepare ultra-small and amorphous bismuth sulfide clusters-supported silica-based hybrid micellar system.The results show that the functional hybrid micellar system has excellent photothermal performance,and its photothermal conversion efficiency is up to 86.93%,which may be attributed to monodisperse and stable loading of bismuth sulfide clusters with defective structure in the organosilica framework of hybrid micellar system,which enhances light absorption capacity of bismuth sulfide nanomaterials in the near-infrared wavelength range.The in vitro antimicrobial experiments show that this bismuth-containing system exhibits excellent photothermal antibacterial properties under irradiation of 808 nm near-infrared laser and good biocompatibility.