文献类型：期刊文献

中文题名：5-氯-2-(4-氯-苯氧基)-苯酚的合成

英文题名：Synthetic Process of Active Antimicrobial 5-Chloro-2-(4-Chloro-Phenoxy)Phenol

作者：焦家俊[1];韩海军[1];侯钰暄[1];王静[1]

机构：[1]华东理工大学化学与分子工程学院,上海200237

年份：2007

卷号：33

期号：1

起止页码：75

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;EI(收录号：20071510544966);Scopus;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：杀菌剂;5-氯-2-(4-氯-苯氧基)-苯酚;过氧乙酸;Baeyer-Villiger氧化

外文关键词：antimicrobial; 5-chloro-2-（4-chloro-phenoxy）-phenol; acetyl hydroperoxide; Baeyer-Villiger oxidization

摘要：以对二氯苯为起始原料,经过乙酰基化、醚化、过氧乙酸氧化、水解得到5-氯-2-(4-氯-苯氧基)-苯酚,改良后的工艺使终产品收率达32.9%,醚化反应改用氢氧化钾代替碳酸钾与对氯苯酚反应制备亲核试剂,均三甲苯代替二甲苯为溶剂,醚化产物收率达到69.2%。氧化反应使用乙酸酐与过氧化氢(w=0.30)反应制备氧化剂,乙酸为溶剂,氧化反应收率达到72.7%。
This paper presents an improved process for the synthesis of 5-chloro-2-（4-chloro-phenoxy）- phenol by using 1,4-dichlorobenzene as a starting material, through acetylation, etherification, acetylperoxide oxidation and hydrolysis,the total yield reached 32.90%. Mesitylene instead of xylene,was used as solvent,and potassium hydroxide instead of potassium carbonate,was used to react with phenol to generate nucleophilic reagent during etherization,through which the yield reached 69.2 %. During the acetylperoxide oxidation, with acetic acid as solvent,peracetiacid as oxidizing agent prepared through the reaction of acetic anhydride with hydrogen peroxide（w=0.30）,the yield reached 72.7 %.