文献类型：期刊文献

英文题名：Synthesis and nematicidal activity of piperazinedione derivatives based on the natural product Barettin

作者：Sun, Haiyang[1];Li, Hui[1];Wang, Jiayi[1];Song, Gonghua[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China

年份：2018

卷号：29

期号：6

起止页码：977

外文期刊名：CHINESE CHEMICAL LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000436910700058)】；

基金：This work was financially supported by the National Natural Science Foundation of China (No. 21572060).

语种：英文

外文关键词：5-HT; Barettin; Nature product; Nematicidal activity; Piperazinedione derivatives

摘要：Nematodes are serious constraints of crop production worldwide. However, the traditional nematicides suffer from the side-effects, including environmental and human toxicity. Herein, more than 70 novel piperazinedione derivatives based on the natural product Barettin were synthesized and evaluated against the root-knot nematode Meloidogyne incognita (M. incognita). While most of synthesized compounds exhibited certain nematicidal activity at high concentration, the best one showed a nematicidal activity of 75% at 2.4 mu mol/L. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.