文献类型：期刊文献

英文题名：Highly Tough, Stretchable, and Enzymatically Degradable Hydrogels Modulated by Bioinspired Hydrophobic β-Sheet Peptides

作者：Xiang, Yanxin[1,2];Zhang, Jiali[1,2];Mao, Huanv[1,2];Yan, Zexin[1,2];Wang, Xuebin[1,2];Bao, Chunyan[1,2];Zhu, Linyong[1,2]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, Key Lab Adv Mat,Inst Fine Chem,Joint Res Ctr, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Joint Int Res Lab Precis Chem & Mol Engn, Inst Fine Chem,Joint Res Ctr,Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

年份：2021

卷号：22

期号：11

起止页码：4846

外文期刊名：BIOMACROMOLECULES

收录：;EI(收录号：20214611157784);WOS:【SCI-EXPANDED(收录号:WOS:000717390400036)】；

基金：This work was supported by the National Key Research and Development Project (2019YFA0110500), NSFC (22171085), and Shanghai Sc i. Tech. Comm. (21ZR1415500). The authors thank the Research Centre of Analysis and Test of the East China University of Science and Technology for help with the characterization.

语种：英文

外文关键词：Energy dissipation - Drug delivery - Hydrophobicity - Tensile strength - Peptides - Scaffolds - Medical applications - Polyvinyl alcohols - Biocompatibility - Biodegradability - Compressive strength

摘要：Peptide-based supramolecular hydrogels have attracted great attention due to their good biocompatibility and biodegradability and have become promising candidates for biomedical applications. The bottom-up self-assembly endows the peptides with a highly ordered secondary structure, which has proven to be an effective strategy to improve the mechanical properties of hydrogels through strong physical interactions and energy dissipation. Inspired by the excellent mechanical properties of spider-silk, which can be attributed to the rich beta-sheet crystal formation by the hydrophobic peptide fragment, a hydrophobic peptide (HP) that can form a beta-sheet assembly was designed and introduced into a poly(vinyl alcohol) (PVA) scaffold to improve mechanical properties of hydrogels by the cooperative intermolecular physical interactions. Compared with hydrogels without peptide grafting (P-HPO), the strong beta-sheet self-assembly domain endows the hybrid hydrogels (P-HP20, P-HP29, and P-HP37) with high strength and toughness. The fracture tensile strength increased from 0.3 to 2.1 MPa (7 times), the toughness increased from 0.4 to 21.6 MJ m(-)(3) (54 times), and the compressive strength increased from 0.33 to 10.43 MPa (31 times) at 75% strain. Moreover, the hybrid hydrogels are enzymatically degradable due to the dominant contribution of the beta-sheet assembly for network cross-linking. Combining the good biocompatibility and sustained drug release of the constructed hydrogels, this hydrophobic beta-sheet peptide represents a promising candidate for the rational design of hydrogels for biomedical applications.