文献类型：期刊文献

英文题名：Polypeptide self-assemblies: nanostructures and bioapplications

作者：Cai, Chunhua[1];Lin, Jiaping[1];Lu, Yingqing[1];Zhang, Qian[1];Wang, Liquan[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, State Key Lab Bioreactor Engn, Key Lab Ultrafine Mat,Minist Educ,Sch Mat Sci & E, Shanghai 200237, Peoples R China

年份：2016

卷号：45

期号：21

起止页码：5985

外文期刊名：CHEMICAL SOCIETY REVIEWS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000386342500008)】；

基金：This work was supported by the National Natural Science Foundation of China (51303055, 51573049, 21234002, and 21474029) and the National Basic Research Program of China (2012CB933600). Support from Projects of Shanghai municipality (15QA1401400, 15ZZ028, and 13JC1402000) and Fundamental Research Funds for the Central Universities (22A201514001) is also appreciated.

语种：英文

摘要：Polypeptide copolymers can self-assemble into diverse aggregates. The morphology and structure of aggregates can be varied by changing molecular architectures, self-assembling conditions, and introducing secondary components such as polymers and nanoparticles. Polypeptide self-assemblies have gained significant attention because of their potential applications as delivery vehicles for therapeutic payloads and as additives in the biomimetic mineralization of inorganics. This review article provides an overview of recent advances in nanostructures and bioapplications related to polypeptide self-assemblies. We highlight recent contributions to developing strategies for the construction of polypeptide assemblies with increasing complexity and novel functionality that are suitable for bioapplications. The relationship between the structure and properties of the polypeptide aggregates is emphasized. Finally, we briefly outline our perspectives and discuss the challenges in the field.