文献类型：期刊文献

英文题名：Mitochondria-targeting and ROS-sensitive smart nanoscale supramolecular organic framework for combinational amplified photodynamic therapy and chemotherapy

作者：Tian, Jia[1];Huang, Baoxuan[1];Cui, Zepeng[1];Wang, Peng[1];Chen, Shuai[1];Yang, Guoliang[1];Zhang, Weian[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2021

卷号：130

起止页码：447

外文期刊名：ACTA BIOMATERIALIA

收录：;EI(收录号：20215111336931);WOS:【SCI-EXPANDED(收录号:WOS:000677640500001)】；

基金：This study was financially supported by the National Natural Science Foundation of China (Nos. 51803058, 21875063).

语种：英文

外文关键词：Host-guest interaction; Photodynamic therapy; Supramolecular photosensitizer; Porphyrin

摘要：Owing to their reversibly dynamic features, and the regularity of their architectures, supramolecular organic frameworks (SOFs) have attracted attention as new porous materials. Herein, we propose a smart SOF platform for enhanced photodynamic therapy, where the SOF with a superior mitochondria-targeting capability could be cleaved by reactive oxygen species (ROS) produced by itself for highly enhancing PDT. Moreover, it can further work as a platform for carrying chemo-therapeutic drug doxorubicin for synergistic chemo-photodynamic therapy. The SOF is constructed by combining a tetra- beta-cyclodextrin-conjugated porphyrin photosensitizer and a ROS-sensitive thioketal linked adamantane dimer utilizing a host-guest supramolecular strategy. The unique supramolecular framework not only completely resolves the aggregation caused quenching of porphyrin photosensitizers but also endows them with significantly enhanced water-solubility. The in vitro and in vivo results demonstrate that the SOF could be targeted onto mitochondria by confocal imaging, and dissociated by ROS generated by itself, leading to autonomous release of porphyrin photosensitizers and DOX for high anti-cancer activity. It is believed that the strategy using a SOF has the potential of being used to construct versatile agents for combined therapies.