文献类型：期刊文献

英文题名：α-Amino acid N-thiocarboxyanhydrides: A novel synthetic approach toward poly(α-amino acid)s

作者：Tao, Xinfeng[1,2,3];Li, Min-Hui[1,2,4];Ling, Jun[1]

机构：[1]Zhejiang Univ, Dept Polymer Sci & Engn, MOE Key Lab Macromol Synth & Functionalizat, Hangzhou 310027, Zhejiang, Peoples R China;[2]PSL Univ Paris, Chim ParisTech, CNRS, Inst Rech Chim Paris,UMR8247, 11 Rue Pierre & Marie Curie, F-75005 Paris, France;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Shanghai Key Lab Adv Polymer Mat,Key Lab Ultrafin, Shanghai 200237, Peoples R China;[4]Beijing Univ Chem Technol, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, 15 North Third Ring Rd, Beijing 100029, Peoples R China

年份：2018

卷号：109

起止页码：26

外文期刊名：EUROPEAN POLYMER JOURNAL

收录：;EI(收录号：20183705795538);WOS:【SCI-EXPANDED(收录号:WOS:000454974800004)】；

基金：Financial support from the National Natural Science Foundation of China (21674091 & 21528402), the Fundamental Research Funds for the Central Universities (2016QNA4030), French National Research Agency (project ANR-16-CE29-0028) and the (project 21528402) is acknowledged.

语种：英文

外文关键词：Polypeptides; Polypeptoids; Ring opening polymerization; N-thiocarboxyanhydrides; Sarcosine

摘要：Poly(alpha-amino acid)s, containing amino acid repeat units, are remarkable biomaterials with similar structures to protein, which are mainly synthesized by solid phase peptide synthesis, ring opening polymerization of N-carboxyanhydrides, polymerization of activated urethane derivatives of alpha-amino acids and so on. alpha-Amino acid N-thiocarboxyanhydride (NTA) and N-substituted glycine N-thiocarboxyanhydride (NNTA) have recently emerged as a subject of scientific interest due to their easy synthesis and purification in open air, long shelf-life and well controlled polymerization to produce poly(alpha-amino acid)s. In this feature article, we review the history and the recent development on the design of NTA monomers, and summarize the recent advances in poly(alpha-amino acid)s synthesis through ring-opening polymerization of NTA and NNTA by using different initiators and reaction mediums. We also highlight the applications of poly(alpha-amino acid) materials resulting from NTA polymerization.