文献类型：期刊文献

英文题名：Organocatalytic Asymmetric Inverse-Electron-Demand Diels-Alder Reaction of Pyrrolidone-Dienes with Enals

作者：Wu, Shu-Xiao[1,2];Gu, Bo-Qi[1,2];Xu, Hui[1,2];Zheng, Xing[1,2];Luo, Xiaoyan[1,2];Deng, Wei-Ping[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2019

卷号：361

期号：18

起止页码：4302

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000480990600001)】；

基金：This work is supported by the National Natural Science Foundation of China (No. 21572053) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：asymmetric catalysis; pyrrolidone-diene; inverse-electron-demand Diels-Alder reaction; chiral secondary amines; hexahydro-isoindol-1-one

摘要：A new pyrrolidone-diene synthon was devised, and the inverse-electron-demand Diels-Alder reaction of pyrrolidone-dienes with enals catalyzed by chiral secondary amines has been disclosed. A variety of enantioenriched, multifunctionalized hexahydro-isoindol-1-one derivatives were obtained in good yields (up to 75%) with excellent stereoselectivities (up to >20:1 dr and >99% ee).