文献类型：期刊文献

中文题名：N-甲基-N-异丙基胺基磺酰胺的合成

英文题名：The Synthesis of N-Methyl-N-isopropyl Sulfonamide

作者：汤阿萍[1];廖道华[1];牛纪凤[1];解西军[1];高倩[1];李爱军[1];陈立鹏[1]

机构：[1]华东理工大学药学院,上海200237

年份：2013

卷号：52

期号：10

起止页码：721

中文期刊名：农药

外文期刊名：Agrochemicals

收录：CSTPCD;;北大核心:【北大核心2011】；CSCD:【CSCD_E2013_2014】；

语种：中文

中文关键词：N-甲基-N-异丙基磺酰胺;苯嘧磺草胺;合成

外文关键词：N-methyl-N-isopropyl sulfonamide; saflufenacil; synthesis

摘要：[目的]旨在探索并优化出一条适合工业化生产N-甲基-N-异丙基胺基磺酰胺的工艺路线。[方法]氯磺酰异氰酸酯与甲酸水溶液反应得到氨基磺酰氯,然后与N-甲基-N-异丙基胺反应得到目标产物N-甲基-N-异丙基胺基磺酰胺。[结果]反应总收率为62.7%,产物与中间体经1H NMR、MS等进行了表征。[结论]该路线收率较高,操作简便,可作为工业生产路线。
[Aims] This article aims to explore and optimize a reasonable synthesis route of N-methyl-N-isopropyl sulfonamide on industrial scale. [Methods] Amino sulfonyl chloride was synthesized from chloriosulfonyl isocyanate and aqueous formic acid, then reacted with N-methy-N-isopropyl amine to get the target product. [Results] The total yield was 62.7%. The products and intermediates were determined by H NMR and MS and so on. [Conclusions] The yield is improved and the process is simplified, which can be used in industry.