文献类型：期刊文献

中文题名：以ZnO微球为模板制备硫酸葡聚糖／鱼精蛋白胶囊及其缓释行为

英文题名：Preparation of Multilayer Dextran Sulfate/Protamine Capsules Templated on ZnO Microspheres and Their Drug Controlled Release Behavior

作者：杨晓玲[1];乔擎宇[1];曹慧敏[1];朱以华[1]

机构：[1]华东理工大学材料科学与工程学院,超细材料制备与应用教育部重点实验室,上海200237

年份：2008

卷号：8

期号：1

起止页码：152

中文期刊名：过程工程学报

外文期刊名：The Chinese Journal of Process Engineering

收录：CSTPCD;;EI(收录号：20081111147504);Scopus;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

基金：国家自然科学基金资助项目(编号:20676038);教育部科学技术研究重点基金资助项目(编号:107045)

语种：中文

中文关键词：层层自组装;氧化锌微球;鱼精蛋白;硫酸葡聚糖;载药

外文关键词：layer-by-layer self-assembly; ZnO microspheres; protamine; dextran sullate; drug carrier

摘要：以ZnO微球为模板,利用层层自组装的方法制备了壁材为鱼精蛋白(PRM)和硫酸葡聚糖(DXS)的生物可降解聚电解质胶囊.ZnO微球呈良好的单分散性,具有5nm以上的中孔,装载荧光素后生成荧光微球.在ZnO微球外交替吸附鱼精蛋白和硫酸葡聚糖,制得核?壳型ZnO/(DXS/PRM)8复合微球;采用稀HAC溶液去除ZnO模板后,可生成(DXS/PRM)8胶囊.以水溶性多柔米星药物分子作为目标物,研究了该胶囊的载药和释放行为.结果显示,该(DXS/PRM)8胶囊对多柔米星药物分子具有明显的缓释性.
Ultrathin polyelectrolyte capsules were produced by layer-by-layer assembling of biodegradable polyelectrolytes, dextran sulfate （DXS） and protamine （PRM）, on ZnO microspheres followed by the cores decomposition with dilute HAC solution. ZnO microspheres were well mono-dispersed and had around 5 nm intermediate size pores, which could be used as fluorescein delivery. PRM and DXS formed regular growing stable multilayers on ZnO microspheres, thus formed ZnO/（DXS/PRM）8 core-shell microspheres. After removal of ZnO template, （DXS/PRM）8 capsules were fabricated. The loaded drug amount and controlled release behavior of hollow capsules were examined in the sample of dexorubicin hydrochloride （DOX）. The result shows that （DXS/PRM）8 demonstates obvious controlled release of DOX drug.