文献类型：期刊文献

英文题名：Transition Metal-Free Cascade Reactions of Alkynols to Afford Isoquinolin-1(2H)-one and Dihydroisobenzofuran Derivatives

作者：Li, Deng Yuan;Shi, Ke Ji;Mao, Xiao Feng;Chen, Guo Rong;Liu, Pei Nian[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2014

卷号：79

期号：10

起止页码：4602

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20142117754256);WOS:【SCI-EXPANDED(收录号:WOS:000336199800039)，CCR-EXPANDED(收录号:WOS:000336199800039)】；

基金：This work was supported by the National Natural Science Foundation of China (Project Nos. 21172069, 21190033, and 21372072), the Innovation Program of Shanghai Municipal Education Commission (Project No. 12ZZ050), the Basic Research Program of the Shanghai Committee of Science and Technology (Project No. 13NM1400802), NCET (NCET-13-0798), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Potassium compounds

摘要：Transition metal-free cascade reactions of alkynols with imines have been achieved using potassium tert-butoxide as catalyst. Switching the reaction solvent gives two kinds of products in good yield: isoquinolin-1(2H)-one derivatives and dihydroisobenzofuran derivatives. This approach was used to generate the natural product 8-oxypseudopalmatine in a two-step procedure from commercially available starting materials. Additionally, multicomponent reactions of alkynols, aldehydes, and amines were also successfully achieved to afford isoquinolin-1(2H)-one derivatives.