文献类型：期刊文献

英文题名：Eradicating Biofilms: Decoding Persistent Mechanisms and Combating Therapeutic Strategies

作者：Liu, Yaping[1];Chen, Ran[1];Liu, Shangpeng[1];Chen, Jing[4];Sun, Min[3];Fan, Zhen[1];Du, Jianzhong[2,3]

机构：[1]Tongji Univ, Sch Mat Sci & Engn, Dept Polymer Mat, Shanghai 201804, Peoples R China;[2]Tongji Univ, Sch Mat Sci & Engn, Key Lab Adv Civil Engn Mat, Minist Educ, 4800 Caoan Rd, Shanghai 201804, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China;[4]Shanghai BioGerm Med Technol Co Ltd, Shanghai 201401, Peoples R China

年份：2026

卷号：15

期号：6

外文期刊名：ADVANCED HEALTHCARE MATERIALS

收录：;EI(收录号：20254419441426);WOS:【SCI-EXPANDED(收录号:WOS:001605741800001)】；

基金：This research was supported by the National Natural Science Foundation of China (52222306, 22335005, 22475154, and 22305177), the International Scientific Collaboration fund of Science and Technology Commission of Shanghai Municipality (23520710900), Innovation Program of Shanghai Municipal Education Commission (2023ZKZD28), Shanghai Rising-Star Program (Sailing, 23YF1433000), and the Fundamental Research Funds for the Central Universities. Dr. Erik Jan Cornel (Ph.D. in chemistry, University of Sheffield, United Kingdom) helped to review and revise the entire manuscript.

语种：英文

外文关键词：antibiofilm activity; biofilm combating strategies; biofilm formation inhibition; resistance mechanism

摘要：Biofilm-associated infections pose a significant clinical challenge to human health due to their high resistance to conventional antibiotics. The formed biofilm of the dense structure can protect the embedded bacteria against antibiotic and immune system attacks. The biofilm microenvironment exhibits unique chemical and physiological heterogeneity, leading to bacterial survival, adaptation, and persistent infection. Herein, this review summarizes the strategies for combating biofilm-associated infections by understanding the resistance mechanisms driven by biofilm characteristics. These strategies include responding to the biofilm microenvironment; disrupting the physiological barrier by chemically polymerizing the biofilm matrix, enzymatically targeting components of extracellular polymeric substances (EPS) production, and penetrating the biofilm barrier using physical methods (e.g., light, sound, magnetic, or electric fields); modulating metabolic changes within biofilm cells; and disrupting quorum sensing and targeting dormant cells. Therefore, this review aims to discuss the current challenges in anti-biofilm therapies and future directions, providing insights for the development of novel anti-biofilm treatments.