文献类型：期刊文献

英文题名：One-Pot Synthesis of Mesoporous Silica Nanocarriers with Tunable Particle Sizes and Pendent Carboxylic Groups for Cisplatin Delivery

作者：Gu, Jinlou[1];Liu, Jiapeng[1];Li, Yongsheng[1];Zhao, Wenru[1];Shi, Jianlin[1,2]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

年份：2013

卷号：29

期号：1

起止页码：403

外文期刊名：LANGMUIR

收录：;EI(收录号：20130315905886);WOS:【SCI-EXPANDED(收录号:WOS:000313305900048)】；

基金：This work was financially supported by the National Basic Research Program of China (973 Program, 2012CB933602), Research Fund for the Doctoral Program of Higher Education (No. 20090074120009), Natural Science Foundation of China (No. 51072053, 21001043), the Fundamental Research Funds for the Central Universities (WD 1114004), the Innovation Program of Shanghai Municipal Education Commission (13zz040) and the Nano-Special Foundation for Shanghai Committee of Science and Technology (12 nm0502600).

语种：英文

外文关键词：Controlled drug delivery - Silica nanoparticles - Targeted drug delivery - Mesoporous materials - Lanthanum compounds - Solutions

摘要：Mesoporous silica nanocarriers with tunable particle sizes and different loadings of pendent carboxylic groups were successfully prepared by a straightforward and reproducible strategy, in which carboxyethylsilanetriol sodium salt was co-condensed with tetraethoxyorthosilicate to introduce the carboxylic groups. The key in this strategy was to separate the synthesis process into two steps of the nuclei formation and particle growth. The uniform particle size and ordered structure of the synthesized nanocarriers were manifested by several techniques such as XRD, TEM, SEM, and BET. DLS measurement illustrated that nanocarriers could be well suspended in aqueous solution. The integration and content tunability of the carboxylic groups within mesoporous silica nanoparticles (MSNs) were verified by FT-IR and Si-29 NMR The inherent carboxylic units on the obtained carboxylic group modified MSNs (MSNs-C) effectively enhanced the capture and tailored the release properties of the anticancer drug of cisplatin. The accumulation of drug in the HeLa cells was greatly enhanced due to the highly efficient platinum uptake efficiency transported by the synthesized nanocarriers. The drug encapsulated in the MSNs-C exhibited a higher antitumor activity than free cisplatin against both MCF-7 and HeLa cells.