文献类型：期刊文献

英文题名：'Click' to bidentate bis-triazolyl sugar derivatives with promising biological and optical features

作者：Song, Zhuo[2,3];He, Xiao-Peng[2,3,4];Jin, Xiao-Ping[2,3];Gao, Li-Xin[1];Sheng, Li[1];Zhou, Yu-Bo[1];Li, Jia[1];Chen, Guo-Rong[2,3]

机构：[1]Chinese Acad Sci, Natl Ctr Drug Screening, State Key Lab Drug Res, Shanghai Inst Mat Med,Shanghai Inst Biol Sci, Shanghai 201203, Peoples R China;[2]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China;[4]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2011

卷号：52

期号：8

起止页码：894

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000287273000013)】；

基金：Project supported by National Natural Science Foundation of China (Grant No. 20876045, No. 30801405), National Basic Research Program of China (No. 2007CB914201), National Science & Technology Major Project of China 'Key New Drug Creation and Manufacturing Program' (No. 2009ZX09302-001), Shanghai Science and Technology Community (No. 10410702700, 09DZ2291200) and Chinese Academy of Sciences (No. KSCX2-YW-R-168). X.-P.H. also gratefully acknowledges the French Embassy in Beijing, PR China for a co-tutored doctoral fellowship and his French co-advisor Professor Juan Xie (ENS Cachan, Paris, France). Professor Jian-Li Hua (East China University of Science and Technology) is warmly thanked for her critical reading on the paper.

语种：英文

外文关键词：Click reaction; PTP1B inhibitor; Ni2+ sensor; Glycosyl bis-triazole; Bidentate O-glucoside

摘要：Bidentate 1-O-methyl-alpha-D-pyranoglucosides bearing two triazolyl alpha-ketoester groups on the 2,6- or 3,4-positions of sugar scaffold were efficiently synthesized via Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition (click reaction) in good yields. These newly featured sugar derivatives displayed favorable inhibitory activity on protein tyrosine phosphatase 1B (PTP1B) and unexpected selective fluorescence quenching in the presence of Ni2+. (C) 2011 Elsevier Ltd. All rights reserved.