文献类型：专利

英文题名：Preparation of 5-aminobenzofuran-2-carboxylic ester by reacting salicyl aldehyde with benzene diazonium, and carrying etherification, ring-closing reaction, and reducing reaction

作者：GUO J;HUANG P;SHEN Y;TAO J;WANG C;WEN X;ZHOU C;ZUO H

机构：[1]UNIV EAST CHINA SCI & TECHNOLOGY;[2]UNIV EAST CHINA SCI&TECHNOLOGY;[3]ZHEJIANG KESHENG DYESTUFF CHEM CO LTD

申请号：CN101607950-A

申请日：2009-07-03

公开日：2009-12-23

语种：英文

收录：DERWENT

摘要：NOVELTY - Preparation of 5-aminobenzofuran-2-carboxylic ester comprises reacting salicyl aldehyde with benzene diazonium to obtain 1-phenyl-azo-2-1, 2-phenyl aldehyde; and subjecting 1-phenyl-azo-2-1, 2-phenyl aldehyde and methyl ester containing compound to etherification, ring-closing reaction, and reducing reaction to obtain 5-aminobenzofuran-2-carboxylic ester USE - Method for preparing 5-aminobenzofuran-2-carboxylic ester (claimed). ADVANTAGE - The method provides high reaction selectivity, uses simple operation, and is capable of carrying out at large scale industry. DETAILED DESCRIPTION - Preparation of 5-aminobenzofuran-2-carboxylic ester of formula (I) comprises reacting salicyl aldehyde with benzene diazonium to obtain 1-phenyl-azo-2-1, 2-phenyl aldehyde; and subjecting 1-phenyl-azo-2-1, 2-phenyl aldehyde and methyl ester containing compound of formula XCH2COOR to etherification, ring-closing reaction, and reducing reaction to obtain 5-aminobenzofuran-2-carboxylic ester. R=1-5C alkyl with straight or branched chain; and X=F, Cl, Br or I.