文献类型：期刊文献

英文题名：Zwitterionic Spherical Brush Loaded with Epigallocatechin-3-gallate Inhibits Protein Adsorption and Enhances Anti-Cancer Efficacy

作者：Guo, Jiangtao[1,2];Wang, Mingwei[1,2];Zhang, Shiting[1,2];Zhang, Ziyu[1,2];Zhang, Yuhua[1,2];Wang, Junyou[1,2];Cao, Lu[3];Guo, Xuhong[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem Engn, State Key Lab Chem Engn & Low Carbon Technol, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Key Lab Multiphase Mat Chem Engn, Shanghai 200237, Peoples R China;[3]Fudan Univ, Zhongshan Hosp, Inst Bone & Joint Dis, Dept Orthopaed Surg, Shanghai 200032, Peoples R China

年份：2026

卷号：8

期号：11

起止页码：8223

外文期刊名：ACS APPLIED POLYMER MATERIALS

收录：;EI(收录号：20262420906143);WOS:【SCI-EXPANDED(收录号:WOS:001780415500001)】；

基金：This work was financially supported by Sponsored by Shanghai Pujiang Programme (23PJD024), Henan Provincial Science and Technology Department Key Research and Development Projects (241111313400), State Key Laboratory of Chemical Engineering (No. SKL-ChE-24C01).

语种：英文

外文关键词：zwitterionic polyelectrolyte brushes; gelatin nanoparticles; antifouling; EGCG; drug delivery

摘要：Nanoparticle-based delivery systems for epigallocatechin-3-gallate (EGCG) have been developed to improve its bioavailability and anticancer performance. However, interactions between nanoparticles and nonspecific protein in biological fluids often compromise drug delivery efficacy. To address these, we here introduce zwitterionic poly(sulfobetaine methacrylate) (PSBMA) brushes onto the nanocarrier to inhibit protein adsorption. The resulting PSBMA-grafted gelatin nanoparticles (Gel-PSBMA) exhibited colloidal stability over half a month and antiabsorption exposing to bovine serum albumin (BSA) and fetal bovine serum (FBS). Meanwhile, the PSBMA brush grafting strategy increased EGCG loading capacity, enabled sustained release under both physiological (pH 7.4) and tumor microenvironment conditions (pH 6.5), and retained effective antioxidant activity. Furthermore, in vitro studies showed that EGCG-loaded Gel-PSBMA nanoparticles (Gel-PSBMA@EGCG) enhanced cytotoxicity against HeLa cells, compared with free EGCG. These results suggest that zwitterionic brush-modified nanoparticles offer an effective platform for optimizing polyphenolic compound delivery.