文献类型：期刊文献

中文题名：介孔硅酸镁改性硫酸钙骨水泥的降解及成骨性

英文题名：Degradability and Osteogenesis of Mesoporous Magnesium Silicate Modified Calcium Sulphate Bone Cement

作者：陈洁[1];董谢平[2];刘争卉[1];胡兴龙[1];魏杰[1]

机构：[1]华东理工大学超细材料制备与应用教育部重点实验室,上海200237;[2]江西省人民医院骨科,南昌330006

年份：2016

卷号：32

期号：6

起止页码：935

中文期刊名：无机化学学报

外文期刊名：Chinese Journal of Inorganic Chemistry

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000380083500002)】；北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：国家自然科学基金(No.81271705;31271031);国家科技支撑计划(No.2013BAI05B10)资助项目

语种：中文

中文关键词：介孔硅酸镁;硫酸钙;复合骨水泥;降解性;成骨性

外文关键词：mesoporous magnesium silicate; calcium sulfate; composite bone cement; degradability; osteogenesis;

摘要：将介孔硅酸镁(m-MS)掺杂到硫酸钙(CS)中,制备了一种新型复合骨水泥(m-MSC)。结果显示:掺入m-MS,延长了m-MSC的固化时间;提高了其降解速率;掺入m-MS可中和CS降解产生的酸性物质,缓解p H值下降。体外细胞实验显示:m-MSC能促进MC3T3-E1细胞增殖和分化;动物体内植入实验显示:m-MSC的成骨量和Ⅰ型胶原阳性表达率都显著高于CS。
A novel bone cement of mesoporous magnesium silicate and calcium sulfate composite（m-MSC） was fabricated by introducing mesoporous magnesium silicate（m-MS） into calcium sulfate bone cement（CS）. The results showed that the addition of m-MS into CS prolonged the setting time and promoted the degradability of the m-MSC, and neutralized acid substance produced by CS degradation. In cell culture experiments, the result showed that the m-MSC could promote the proliferation and differentiation of MC3T3-E1 cells. In addition, the results of m-MSC histological elevation from bone trauma model revealed that massive bony tissue and Col-Ⅰformed were better than CS after 12 weeks, indicating good osteogenesis of the m-MSC.