文献类型：期刊文献

中文题名：Preparation and characterization of m PEG grafted chitosan micelles as 5-fluorouracil carriers for effective anti-tumor activity

英文题名：Preparation and characterization of m PEG grafted chitosan micelles as 5-fluorouracil carriers for effective anti-tumor activity

作者：Dong-Jun Fu[1];Yu Jin[1];Mu-Qing Xie[1];Ya-Jing Ye[1];Dong-Dong Qin[1];Kai-Yan Lou[1,2,3];Yan-Zuo Chen[1];Feng Gao[1,2,3]

机构：[1]Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology;[2]Shanghai Key Laboratory of Functional Materials Chemistry, East China University of Science and Technology;[3]Shanghai Key Laboratory of New Drug Design, East China University of Science and Technology

年份：2014

卷号：25

期号：11

起止页码：1435

中文期刊名：Chinese Chemical Letters

外文期刊名：中国化学快报（英文版）

收录：CSTPCD;;Scopus;CSCD:【CSCD2013_2014】；PubMed;

基金：support from the Fundamental Research Funds for the Central Universities(No.WY1213013ECUST);supported by Science and Technology Commission of Shanghai Municipality(STCSM,contract Nos.11DZ2260600 and 10DZ2220500)

语种：英文

中文关键词：Self-assembled micelles Methoxy polyethylene glycol grafted chitosan 5-Fluorouracil Controlled-release

外文关键词：Self-assembled micelles Methoxy polyethylene glycol grafted chitosan 5-Fluorouracil Controlled-release

摘要：The objective of this study was to investigate the potential of methoxy polyethylene glycol（m PEG）grafted chitosan（m PEG-g-CS） to be used as a drug carrier. m PEG-g-CS was successfully synthesized by one-step method with formaldehyde. The substitution degree of m PEG on chitosan was calculated by elemental analysis and was found to be（3.23 0.25）%. m PEG-g-CS self-assembled micelles were prepared by ultrasonic method with the controlled size of 178.5–195.1 nm and spherical morphology. Stable dispersion of the micelles was formed with the zeta potential of 2.3–30.2 m V. 5-Fluorouracil（5-FU）, an anticancer chemotherapy drug, was used as a model drug to evaluate the efficiency of the new drug delivery carrier. The loading efficiency of 5-FU was（4.01 0.03）%, and the drug-loaded m PEG-g-CS self-assembled micelle showed a controlled-release effect. In summary, the m PEG-g-CS self-assembled micelle is proved to be a promising carrier with controlled particle size and controlled-release effect. Therefore, it has great potential for the application as 5-FU carriers for effective anti-tumor activity.
The objective of this study was to investigate the potential of methoxy polyethylene glycol（m PEG）grafted chitosan（m PEG-g-CS） to be used as a drug carrier. m PEG-g-CS was successfully synthesized by one-step method with formaldehyde. The substitution degree of m PEG on chitosan was calculated by elemental analysis and was found to be（3.23 0.25）%. m PEG-g-CS self-assembled micelles were prepared by ultrasonic method with the controlled size of 178.5–195.1 nm and spherical morphology. Stable dispersion of the micelles was formed with the zeta potential of 2.3–30.2 m V. 5-Fluorouracil（5-FU）, an anticancer chemotherapy drug, was used as a model drug to evaluate the efficiency of the new drug delivery carrier. The loading efficiency of 5-FU was（4.01 0.03）%, and the drug-loaded m PEG-g-CS self-assembled micelle showed a controlled-release effect. In summary, the m PEG-g-CS self-assembled micelle is proved to be a promising carrier with controlled particle size and controlled-release effect. Therefore, it has great potential for the application as 5-FU carriers for effective anti-tumor activity.