文献类型：期刊文献

英文题名：Synthesis of N-(α-Fluorovinyl)azoles by the Reaction of Difluoroalkenes with Azoles

作者：Xiong, Yang[1];Zhang, Xuxue[1];Huang, Tao[1];Cao, Song[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2014

卷号：79

期号：14

起止页码：6395

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20143017988809);WOS:【SCI-EXPANDED(收录号:WOS:000339368300001)，CCR-EXPANDED(收录号:WOS:000339368300001)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (Grant Nos. 21272070, 21072057), the National Basic Research Program of China (973 Program, 2010CB126101), and the Twelfth Five-year Plan of China (2011BAE06B01-15).

语种：英文

摘要：A mild and versatile method for the construction of C-N bonds by the reaction of (2,2-difluorovinyl)arenes with various N-H-containing heterocycles in the presence of K3PO4 has been developed. The reaction proceeded efficiently at room temperature (25 degrees C) affording the (E)-N-alpha-fluorovinyl derivatives of azoles 3 in good to excellent yields with relatively high stereoselectivity.