文献类型：期刊文献

英文题名：Cu(I) Metal-Organic Framework Composites with AgCl/Ag Nanoparticles for Irradiation-Enhanced Antibacterial Activity against E. coli

作者：Mao, Fangxin[1];Su, Yonghua[2,3];Sun, Xiaoying[2,3];Li, Bin[3,4];Liu, Peng Fei[1]

机构：[1]East China Univ Sci & Technol, Shanghai Engn Res Ctr Hierarch Nanomat, Sch Mat Sci & Engn, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western M, Dept Dermatol, Shanghai 200437, Peoples R China;[3]Shanghai Acad Tradit Chinese Med, Inst Dermatol, Shanghai 201203, Peoples R China;[4]Shanghai Skin Dis Hosp, Dept Dermatol, Shanghai 200443, Peoples R China

年份：2023

外文期刊名：ACS OMEGA

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000911916300001)】；

基金：This work was financially supported by grants from the Clinical Research Plan of SHDC (No. SHDC2020CR3097B) , the National Natural Science Foundation of China (52103340 and 82174383) , the China Postdoctoral Science Foundation Funded Project (2020M681201) , and the Sha n g h a i Sailing Program (No. 20YF1450400) .

语种：英文

摘要：Metal-organic frameworks (MOFs) have emerged as prospective antibacterial agents or synergistic agents for their versatile chemical building components and structures. In this work, copper(I) halide MOFs of Cu(I)bpyCl (bpy = 4,4 '-bipyridine) composited with AgCl/Ag nanoparticles were synthesized, and their antibacterial activities were measured against Escherichia coli and Staphylococcus aureus. The attached chlorine in Cu(I)2Cl2 nodes of the MOFs served as loading sites for silver ions, in which AgCl and concomitant metallic Ag nanoparticles were in situ generated. Exceptional antibacterial activity against E. coli was realized with a minimum inhibitory concentration (MIC) of similar to 7.8 mu g mL-1, while the MIC value was similar to 16 mu g mL-1 against S. aureus. Enhanced antibacterial activity against E. coli with light irradiation was measured by the disk diffusion method compared with that under dark conditions.