文献类型：期刊文献

英文题名：Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery

作者：Li, Yulin[1,2];Maciel, Dina[1];Rodrigues, Joao[1];Shi, Xiangyang[1,3];Tomas, Helena[1]

机构：[1]Univ Madeira, CQM, MMRG, P-9000390 Funchal, Portugal;[2]E China Univ Sci & Technol, Engn Res Ctr Biomed Mat Minist Educ, State Key Lab Bioreactor Engn, Key Lab Ultrafine Mat Minist Educ, Shanghai 200237, Peoples R China;[3]Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

年份：2015

卷号：115

期号：16

起止页码：8564

外文期刊名：CHEMICAL REVIEWS

收录：;EI(收录号：20153601232671);WOS:【SCI-EXPANDED(收录号:WOS:000360321300009)】；

基金：This work was mainly supported by Fundacao para a Ciencia e a Tecnologia (FCT) with funds from the Portuguese Government (CQM Project PEstOE/QUI/UI0674/2014 and Project PTDC/CTM-NAN/116788/2010). Additionally, the FCT Science 2008 Programme (Y.L.) and the FCT Ph.D. grant (D.M., SFRH/BD/102123/2014) are acknowledged. X.S. thanks FCT and Santander Bank for the Invited Chair in Nanotechnology. We also wish to express our gratitude for financial support from the National Basic Research Program of China (973 Program, no. 2012CB933600) and the Shanghai Municipal Science Foundation (15ZR1408500).

语种：英文

外文关键词：Biodegradability - Drug interactions - Natural polymers - Biocompatibility - Chemical modification - Controlled drug delivery - Targeted drug delivery - Nanostructured materials - Synthetic polymers

摘要：Recent advances on biodegradable polymer nanogels (NG) for the delivery of drugs/nucleic acids are reviewed. In combination with proper chemical modification, most biodegradable NGs are fabricated on the basis of natural polymers, which have good biocompatibility, biodegradability, and some of them biological signaling activity. On the other hand, synthetic polymers can be produced with a well-defined structure and controllable degradability or through the introduction of degradable cross-links different synthetic polymers have also been utilized in the development of new degradable or partially degradable NGs having less potential immunogenic responses. Various stimuli-sensitive blocks can be introduced into the architecture of NGs, which are able to deliver therapeutics in an intelligent way in the presence of specific chemical or physical stimuli. To improve their intracellular uptake ability and targetability to diseased sites, the surface of the NGs can be decorated with different targeting ligands to achieve optimal therapeutic efficacy while reducing side effects.