文献类型：期刊文献

中文题名：5种LC-MS级试剂的技术指标及适应性检测方法

英文题名：Suitability Test and Technical Indexes for Five LC-MS Grade Solvents

作者：陈浩云[1];凌芳[1];顾小焱[1];蔡璇[2];洪亚云[2];赵红莉[2]

机构：[1]国药集团化学试剂有限公司,上海200002;[2]华东理工大学化学与分子工程学院,上海200237

年份：2018

卷号：40

期号：2

起止页码：147

中文期刊名：化学试剂

外文期刊名：Chemical Reagents

收录：CSTPCD;;北大核心:【北大核心2017】；

语种：中文

中文关键词：LC-MS级试剂;技术指标;分析方法;适应性检测

外文关键词：LC-MS grade solvent ; technical indexes ; analysis method ; suitability test

摘要：液相色谱-质谱联用（LC-MS）检测作为一种常规分析手段,对流动相试剂的纯度要求非常高。然而,国产LC-MS色谱级试剂质量不够稳定,国内难以检索到公开的LC-MS级色谱试剂的技术标准,使得绝大部分科研实验室只能采用进口试剂。因此,建立公开透明的LC-MS级试剂技术指标以及产品分析检测方法意义重大。分析了国内外LC-MS色谱试剂生产现状,以甲醇为例,列出了国外LC-MS甲醇的技术指标,简要概括了各指标的检测方法。并以5种国产LC-MS级试剂（甲醇、乙腈、乙酸乙酯、正己烷、异丙醇）为实验对象,建立了各试剂的LC-MS适应性检测分析方法,同时采用相应的进口LC-MS色谱试剂进行对照,证明了所建方法的可行性。
As a kind of widely used analysis method,liquid chromatography-mass spectrometry（LC-MS） requires mobile phase reagents with extremely high purity.However,the quality of domestic LC-MS grade reagents is not stable.And the absence of technical standards of domestic LC-MS chromatogram reagents has urged most research laboratories to use imported reagents.Therefore,to establish technical indexes and analysis methods of LC-MS grade reagents is of great significance.In this work,the current status of LC-MS grade reagents production both at home and abroad was analyzed.The technical indexes and analysis methods of imported LC-MS grade methanol were listed as an example.With five kinds of domestic LC-MS grade reagents（methanol,acetonitrile,ethyl acetate,n-hexane and isopropanol） as experimental object,the suitability test methods of these solvents were established.In addition,the test results of both domestic and imported reagents were compared,indicating the feasibility of the analysis methods proposed.