文献类型：期刊文献

英文题名：Visible-light photoredox catalyzed hydroacylation of electron-deficient alkenes: carboxylic anhydride as an acyl radical source

作者：Dong, Shupeng[1];Wu, Guibing[1];Yuan, Xiaoqian[1];Zou, Chuncheng[1];Ye, Jinxing[1]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Shanghai Key Lab New Drug Design, Minist Educ,Sch Pharm, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2017

卷号：4

期号：11

起止页码：2230

外文期刊名：ORGANIC CHEMISTRY FRONTIERS

收录：;EI(收录号：20184806137289);WOS:【SCI-EXPANDED(收录号:WOS:000413826400028)，CCR-EXPANDED(收录号:WOS:000413826400028)】；

基金：This work was partially supported by the National Natural Science Foundation of China (21272068, 21572056), the Program for New Century Excellent Talents in University (NCET-13-0800) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Olefins - Addition reactions

摘要：A convenient method mediated by photoredox catalysis for the direct construction of 1,4-dicarbonyl compounds has been developed. Simple aromatic symmetric carboxylic anhydrides or mixed anhydrides (generated in situ) have been utilized as an acyl radical source in addition to different types of Michael acceptors. A wide range of substrates are amenable to this new type of acyl Michael addition under mild conditions with broad functional group tolerance. As an application, a novel four-step synthesis of medicinal agent haloperidol is also presented.