文献类型：期刊文献

中文题名：Biomaterial design for regenerating aged bone:materiobiological advances and paradigmatic shifts

英文题名：Biomaterial design for regenerating aged bone: materiobiological advances and paradigmatic shifts

作者：Dai, Kai[1,2,3,4];Geng, Zhen[5,6];Zhang, Wenchao[1,3];Wei, Xue[1,3];Wang, Jing[1,2,3];Nie, Guangjun[7,8];Liu, Changsheng[1,3,4]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[5]Shanghai Univ, Inst Translat Med, Shanghai 200444, Peoples R China;[6]Shanghai Univ, Natl Ctr Translat Med Shanghai, SHU Branch, Shanghai 200444, Peoples R China;[7]Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China;[8]Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China

年份：2024

卷号：11

期号：5

中文期刊名：National Science Review

外文期刊名：NATIONAL SCIENCE REVIEW

收录：CSTPCD;;EI(收录号：20241515875229);Scopus;WOS:【SCI-EXPANDED(收录号:WOS:001195207200001)】；CSCD:【CSCD2023_2024】；PubMed;

基金： This work was supported by the Basic Science Center Program (T2288102), the Key Program of the National Natural Science Foundation of China (32230059), the National Natural Science Foundation of China (32301123), the Foundation of Frontiers Science Center for Materiobiology and Dynamic Chemistry (JKVD1211002), the Wego Project of Chinese Academy of Sciences ((2020) 005), and the China Postdoctoral Science Foundation (2022M721147).

语种：英文

中文关键词：materiobiology;biomaterial design;aging;bone regeneration;artificial intelligence

外文关键词：materiobiology; biomaterial design; aging; bone regeneration; artificial intelligence

摘要：China’s aging demographic poses a challenge for treating prevalent bone diseases impacting life quality.As bone regeneration capacity diminishes with age due to cellular dysfunction and inflammation,advanced biomaterials-based approaches offer hope for aged bone regeneration.This review synthesizes materiobiology principles,focusing on biomaterials that target specific biological functions to restore tissue integrity.It covers strategies for stem cell manipulation,regulation of the inflammatory microenvironment,blood vessel regeneration,intervention in bone anabolism and catabolism,and nerve regulation.The review also explores molecular and cellular mechanisms underlying aged bone regeneration and proposes a database-driven design process for future biomaterial development.These insights may also guide therapies for other age-related conditions,contributing to the pursuit of‘healthy aging’.
China's aging demographic poses a challenge for treating prevalent bone diseases impacting life quality. As bone regeneration capacity diminishes with age due to cellular dysfunction and inflammation, advanced biomaterials-based approaches offer hope for aged bone regeneration. This review synthesizes materiobiology principles, focusing on biomaterials that target specific biological functions to restore tissue integrity. It covers strategies for stem cell manipulation, regulation of the inflammatory microenvironment, blood vessel regeneration, intervention in bone anabolism and catabolism, and nerve regulation. The review also explores molecular and cellular mechanisms underlying aged bone regeneration and proposes a database-driven design process for future biomaterial development. These insights may also guide therapies for other age-related conditions, contributing to the pursuit of 'healthy aging'. This review exploresthe ongoing material design procedures involving screening of disordered biological functions, artificial intelligence-aided material `elements' selection, in vitro high-throughput fabrication and evaluation, and in vivo verification for clinical translation.