文献类型：期刊文献

英文题名：A highly selective turn-on fluorescent probe based on semi-cyanine for the detection of nitroreductase and hypoxic tumor cell imaging

作者：Yuan, Jun[1];Xu, Yu-Qiong[1];Zhou, Nan-Nan[2];Wang, Rui[2];Qian, Xu-Hong[1];Xu, Yu-Fang[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, State Key Lab Bioreactor Engn, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China

年份：2014

卷号：4

期号：99

起止页码：56207

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20144600184529);WOS:【SCI-EXPANDED(收录号:WOS:000344997800061)】；

基金：We are grateful for the financial support from the State Key Program of National Natural Science of China (21236002), the National Basic Research Program of China (2010CB126100), the National High Technology Research and Development Program of China (2011AA10A207). We appreciate Professor Youjun Yang (School of Pharmacy, East China University of Science and Technology) for the improvements in this paper.

语种：英文

外文关键词：Fluorescence - Tumors

摘要：Based on a semi-cyanine fluorophore, a selective turn-on fluorescent probe semi-CyHP for the detection of nitroreductase (NTR) and hypoxia was designed and synthesized. It can be activated by NTR and to restore the pull-push electronic systems of semi-CyHF, which strongly fluoresces at 556 nm. Besides, the investigation of the hypoxic tumor cell imaging with semi-CyHP was significant with minimal endogenous interference.