文献类型：期刊文献

英文题名：NIR-activated α-Octabutoxy-naphthalocyanine palladium(II) nanoparticles for synergistic photothermal and type ?/II photodynamic therapy of cancer cells

作者：Wang, Yingqiao[1];Feng, Ruitao[2];Jin, Yilan[1];Yang, Hong[1];Chen, Xu[3]

机构：[1]Shanghai Normal Univ, Coll Chem & Mat Sci, Guiling Rd 100, Shanghai 200234, Peoples R China;[2]Shanghai High Sch, Shangzhong Rd 100, Shanghai 200231, Peoples R China;[3]East China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, Meilong Rd 130, Shanghai 200237, Peoples R China

年份：2026

卷号：1048

外文期刊名：JOURNAL OF ORGANOMETALLIC CHEMISTRY

收录：;EI(收录号：20260520000478);WOS:【SCI-EXPANDED(收录号:WOS:001682985200001)】；

语种：英文

外文关键词：Palladium(II) phthalocyanine; NIR absorption; Photodynamic therapy; Photothemal property; Cancer cells

摘要：alpha-Octabutoxy-naphthalocyanine palladium(II), denoted as PdNc(OBu)(8), has been successfully synthesized. To improve water solubility and biocompatibility, we encapsulated it with bovine serum albumin (BSA) to form nanoparticles of PdNc(OBu)(8) NPs. The nanoparticles show strong NIR absorption centered at 825 nm. Under 808 nm laser irradiation, PdNc(OBu)(8) NPs generate both singlet oxygen (O-1(2)) and superoxide radical (O-2(center dot-)). They also act as strong photothermal agents with a photothermal conversion efficiency of similar to 66%. For 4T1 cells, the NIR irradiation of PdNc(OBu)(8) NPs causes marked cell death with the photothermal and type I/II photodynamic effect. All these results supported PdNc(OBu)(8) NPs should be promising for combined type I/II photodynamic and photothermal cancer therapy.