文献类型：期刊文献

英文题名：Automated Chemical Solid-Phase Synthesis of Glycans

作者：Li, Xiaona[1];Yang, You[1]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab New Drug Design,Sch Pharm, Shanghai Frontiers Sci Ctr Biogenet Tech Cell Met, Engn Res Ctr Pharmaceut Proc Chem,Minist Educ, 130 Meilong Rd, Shanghai 200237, Peoples R China

年份：2022

卷号：40

期号：14

起止页码：1714

外文期刊名：CHINESE JOURNAL OF CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000798751400001)】；

基金：Financial support from the National Natural Science Foundation of China (Nos. 21871081, 22071054), the Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission), and the First-Class Discipline Construction and Characteristic Development Guidance Funds for the Central Universities (No. SLC13223002) is gratefully acknowledged.

语种：英文

外文关键词：Carbohydrates; Oligosaccharides; Glycosylation; Solid-phase synthesis; Automated glycan assembly

摘要：Automated chemical solid-phase synthesis is an automation platform for rapid and reliable synthesis of glycans. Since the seminal work of Automated Glycan Assembly (AGA) disclosed by Seeberger in 2001, AGA has evolved from a proof-of-concept to a robust and reliable technology for streamlined production of various types of glycans. Through more than 20 years of unceasing efforts, the major breakthroughs in AGA including linkers, approved building blocks, and synthesizers have been acquired, and numerous influential achievements have been made in complex glycan synthesis. In addition, the HPLC-assisted automated synthesis emerges as a promising automation platform to access glycans. In this review, we highlight the key advances in the field of automated chemical solid-phase synthesis, especially in AGA. The synthesis of representative glycans based on AGA is also described.