文献类型：期刊文献

中文题名：短链脂肪酸调控NLRP3炎症小体通路在慢性肾脏病中的作用及中药干预的研究进展

英文题名：Short-chain fatty acids modulate the role of NLRP3 inflammatory vesicle pathway in CKD and the progress of traditional Chinese medicine intervention

作者：高子恬[1,2];陈彧[2];贺海东[1];唐余燕[1]

机构：[1]复旦大学附属闵行医院(上海市闵行区中心医院肾脏科),上海201199;[2]华东理工大学化学与分子工程学院,教育部结构可控先进功能材料及其制备重点实验室,上海200237

年份：2025

卷号：30

期号：6

起止页码：812

中文期刊名：中国临床药理学与治疗学

外文期刊名：Chinese Journal of Clinical Pharmacology and Therapeutics

收录：;北大核心:【北大核心2023】；

基金：国家自然科学基金(82304948);上海市科委自然基金(24ZR1467170)。

语种：中文

中文关键词：短链脂肪酸;NLRP3炎症小体;中药;慢性肾脏病

外文关键词：short-chain fatty acids;NLRP3 inflam-matory vesicles;traditional Chinese medicine;chronic kidney disease

摘要：肠道菌群代谢产物——短链脂肪酸(shortchain fatty acids,SCFAs)、NLRP3炎症小体以及相互作用的调控已被证明在多种疾病中起到关键作用。而慢性肾脏病(chronic kidney disease,CKD)是一种常见的进展性疾病,其发病机制与肠道菌群代谢产物SCFAs的减少和NLRP3炎症小体的过度激活有关。本文就SCFAs与NLRP3炎症通路在CKD发病机制中的作用进行总结,并对近年来中药干预该炎症通路治疗CKD的研究进行梳理,以为中药治疗CKD的确切机制提供方向和思路。
The regulation of gut flora metabolites-short-chain fatty acids(SCFAs),NLRP3 inflammatory vesicles,and interactions has been shown to play a key role in many diseases.While chronic kidney disease(CKD)is a common progressive disease whose pathogenesis is related to the reduction of SCFAs,a metabolite of intestinal flora,and the over-activation of NLRP3 inflammatory vesicles.In this paper,we summarize the role of SCFAs and NLRP3 inflammatory pathway in the pathogenesis of CKD,and sort out the research on the intervention of traditional Chinese medicine(TCM)in this inflammatory pathway in the treatment of CKD in recent years,so as to provide the direction and ideas for the exact mechanism of TCM in the treatment of CKD.