文献类型：期刊文献

英文题名：Bacteria-triggered on-demand thymol release for salmon preservation: A self-destructive antibacterial strategy

作者：Dong, Yuhe[1];Jia, Xiaohui[1];Wu, Tong[2];Zhu, Wanying[2];Zhang, Zhou[3];Jiang, Tao[1];Yu, Xi[3];Xiao, Ying[3];Feng, Chun[4];Huang, Xiaoyu[5];Zhong, Tian[3]

机构：[1]Macau Univ Sci & Technol, Fac Med, Sch Pharm, Macau, Peoples R China;[2]Macau Univ Sci & Technol, Fac Chinese Med, Macau, Peoples R China;[3]Macau Univ Sci & Technol, Fac Med, Macau, Peoples R China;[4]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai, Peoples R China;[5]Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Fluorine & Nitrogen Chem & Adv Mat, 345 Lingling Rd, Shanghai, Peoples R China

年份：2025

卷号：485

外文期刊名：FOOD CHEMISTRY

收录：;EI(收录号：20251818356517);WOS:【SCI-EXPANDED(收录号:WOS:001486127800001)】；

基金：This study was supported by the Macao FDCT Grants 0005/2024/AGJ, 0009/2023/AFJ, and 0104/2021/A2.

语种：英文

外文关键词：Stimuli-responsive materials; Controlled release; On-demand release; Antibacterial; Food preservation

摘要：To prevent foodborne pathogen invasion in fresh meat during storage, this study develops an enzyme/redox dual-responsive nanomaterial (Thy@MSN-S-S-Casein). Upon encountering bacteria, the casein shell is degraded by bacterial proteases, and glutathione (GSH) cleaves the disulfide bonds on the mesoporous silica nanoparticle (MSN) surface, releasing thymol to combat the bacteria. Trypsin and GSH triggered a cumulative release of 68.37 % thymol from Thy@MSN-S-S-Casein within 48 h, which was significantly higher than the release by trypsin alone (49.93 %) or without any activation (17.33 %). The antibacterial activities of Thy@MSN-S-S-Casein can be triggered by both artificially inoculated bacteria and naturally-infected bacteria on the salmon surfaces, leading to a reduction in the total viable count (TVC) in both experiments. Additionally, it inhibited the deterioration of the salmon fillets' quality indicators and extended their shelf life by about 3 days. This bacteriatriggered release strategy offers a promising self-destructive antibacterial approach for mitigating pathogen outbreaks in food preservation.